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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 569 - 574 (6page)
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Vascular calcification is the heterotopic accumulation of calciumphosphate salts in the vascular tissue and is highly correlatedwith increased cardiovascular morbidity and mortality. In thisstudy, we found that the expression of neuromedin B (NMB)and NMB receptor is upregulated in phosphate-induced calcificationof vascular smooth muscle cells (VSMCs). Silencing ofNMB or treatment with NMB receptor antagonist, PD168368,inhibited the phosphate-induced osteogenic differentiation ofVSMCs by inhibiting Wnt/β-catenin signaling and VSMC apoptosis.
PD168368 also attenuated the arterial calcification in culturedaortic rings and in a rat model of chronic kidney disease. Theresults of this study suggest that NMB?NMB receptor axis mayhave potential therapeutic value in the diagnosis and treatmentof vascular calcification.
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등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Johnson RC / 2006 / Vascular calcification : pathobiological mechanisms and clinical implications / Circ Res 99:1044~1059
Singh A / 2021 / An update on vascular calcification and potential therapeutics / Mol Biol Rep 48:887~896
Leopold JA / 2015 / Vascular calcification : mechanisms of vascular smooth muscle cell calcification / Trends Cardiovasc Med 25:267~274
McCarty MF / 2014 / The molecular biology and pathophysiology of vascular calcification / Postgrad Med 126:54~64
Jensen RT / 2008 / International union of pharmacology. LXVIII. Mammalian bombesin receptors : nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states / Pharmacol Rev 60:1~42
Singh A / 2021 / An update on vascular calcification and potential therapeutics / Mol Biol Rep 48:887~896
Leopold JA / 2015 / Vascular calcification : mechanisms of vascular smooth muscle cell calcification / Trends Cardiovasc Med 25:267~274
McCarty MF / 2014 / The molecular biology and pathophysiology of vascular calcification / Postgrad Med 126:54~64
Jensen RT / 2008 / International union of pharmacology. LXVIII. Mammalian bombesin receptors : nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states / Pharmacol Rev 60:1~42
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