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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 701 - 712 (12page)
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초록· 키워드
오류제보하기
Diabetes is a major risk factor for the progression of vascular disease, contributing to elevated levels of glycoxidation, chronic inflammation and calcification. Tissue engineering emerges as a potential solution for the treatment of vascular diseases however there is a considerable gap in the understanding of how scaffolds and stem cells will perform in patients with diabetes. We hypothesized that adipose tissue-derived stem cells (ASCs) by virtue of their immunosuppressive potential would moderate the diabetes-intensified inflammatory reactions and induce positive construct remodeling. To test this hypothesis, we prepared arterial elastin scaffolds seeded with autologous ASCs and implanted them subdermally in diabetic rats and compared inflammatory markers, macrophage polarization, matrix remodeling, calcification and bone protein expression to control scaffolds implanted with and without cells in nondiabetic rats. ASC-seeded scaffolds exhibited lower levels of CD8+ T-cells and CD68+ pan-macrophages and higher numbers of M2 macrophages, smooth muscle cell-like and fibroblast-like cells. Calcification and osteogenic markers were reduced in ASCseeded scaffolds implanted in non-diabetic rats but remained unchanged in diabetes, unless the scaffolds were first pre-treated with penta-galloyl glucose (PGG), a known anti-oxidative elastin-binding polyphenol. In conclusion, autologous ASC seeding in elastin scaffolds is effective in combating diabetes-related complications. To prevent calcification, the oxidative milieu needs to be reduced by elastin-binding antioxidants such as PGG.
목차
등록된 정보가 없습니다.
참고문헌 (70)
참고문헌 신청
Bierhaus A / 1998 / AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. The AGE concept / Cardiovasc Res 37:586~600
Peterson LR / 2012 / Diabetic cardiovascular disease: getting to the heart of the matter / J Cardiovasc Transl Res 5:436~445
Fein FS / 1990 / Diabetic cardiomyopathy / Diabetes Care 13:1169~1179
Giacco F / 2010 / Oxidative stress and diabetic complications / Circ Res 107:1058~1070
Roger VL / 2011 / Heart disease and stroke statistics--2011 update: a report from the American Heart Association / Circulation 123:e18~e209
Peterson LR / 2012 / Diabetic cardiovascular disease: getting to the heart of the matter / J Cardiovasc Transl Res 5:436~445
Fein FS / 1990 / Diabetic cardiomyopathy / Diabetes Care 13:1169~1179
Giacco F / 2010 / Oxidative stress and diabetic complications / Circ Res 107:1058~1070
Roger VL / 2011 / Heart disease and stroke statistics--2011 update: a report from the American Heart Association / Circulation 123:e18~e209
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