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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 534 - 539 (6page)
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IL-10+ regulatory B (Breg) cells play a vital role in regulating the immune responses in experimental autoimmune encephalomyelitis, colitis, and contact hypersensitivity (CHS). Several stimulants such as lipopolysaccharide (LPS), CD40 ligand, and IL-21 spur the activation and maturation of IL-10+ Breg cells, while the epigenetic mechanism for the IL-10 expression remains largely unknown. It is well accepted that the histone acetylation/ deacetylation is an important mechanism that regulates the expression of IL-10. We found that entinostat, an HDAC inhibitor, stimulated the induction of IL-10+ Breg cells by LPS in vitro and the formation of IL-10+ Breg cells to suppress CHS in vivo. We further demonstrated that entinostat inhibited HDAC1 from binding to the proximal region of the IL-10 expression promoter in splenic B cells, followed by an increase in the binding of NF-κB p65, eventually enhancing the expression of IL-10 in Breg cells.
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참고문헌 (34)
참고문헌 신청
Neta R / 1974 / Specific suppression of delayed hypersensitivity : the possible presence of a suppressor B cell in the regulation of delayed hypersensitivity / J Immunol 113:1716~1725
Mizoguchi A / 2002 / Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation / Immunity 16:219~230
Rosser EC / 2015 / Regulatory B cells : origin, phenotype, and function / Immunity 42:607~612
Junghee Lee / 2010 / Epigenetic modification is linked to Alzheimer’s disease: is it a maker or a marker? / BMB Reports 43(10):649~655
Xu WS / 2007 / Histone deacetylase inhibitors : molecular mechanisms of action / Oncogene 26:5541~5552
Mizoguchi A / 2002 / Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation / Immunity 16:219~230
Rosser EC / 2015 / Regulatory B cells : origin, phenotype, and function / Immunity 42:607~612
Junghee Lee / 2010 / Epigenetic modification is linked to Alzheimer’s disease: is it a maker or a marker? / BMB Reports 43(10):649~655
Xu WS / 2007 / Histone deacetylase inhibitors : molecular mechanisms of action / Oncogene 26:5541~5552
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