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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 165 - 174 (10page)
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Interleukin-32 (IL-32) was originally identified in natural killer (NK) cells activated by IL-2 in 1992. Thus, it was named NK cell transcript 4 (NK4) because of its unknown function at that time. The function of IL-32 has been elucidated over the last decade. IL-32 is primarily considered to be a booster of inflammatory reactions because it is induced by proinflammatory cytokines and stimulates the production of those cytokines and vice versa. Therefore, many studies have been devoted to studying the roles of IL-32 in inflammationassociated cancers, including gastric, colon cancer, and hepatocellular carcinoma. At the same time, roles of IL-32 have also been discovered in other cancers. Collectively, IL-32 fosters the tumor progression by nuclear factor-B (NF-B)- mediated cytokines and metalloproteinase production, as well as stimulation of differentiation into immunosuppressive cell types in some cancer types. However, it is also able to induce tumor cell apoptosis and enhance NK and cytotoxic T cell sensitivity in other cancer types. In this review, we will address the function of each IL-32 isoform in different cancer types studied to date, and suggest further strategies to comprehensively elucidate the roles of IL-32 in a contextdependent manner.
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참고문헌 (75)
참고문헌 신청
Zitvogel L / 2006 / Cancer despite immunosurveillance : immunoselection and immunosubversion / Nat Rev Immunol 6:715~727
Galon J / 2006 / Type, density, and location of immune cells within human colorectal tumors predict clinical outcome / Science 313:1960~1964
Mosmann TR / 1986 / Two types of murine helper T cell clone. I. definition according to profiles of lymphokine activities and secreted proteins / J Immunol 136:2348~2357
Sakaguchi S / 2010 / FOXP3+ regulatory T cells in the human immune system / Nat Rev Immunol 10:490~500
O'Sullivan KE / 2014 / The role of inflammation in cancer of the esophagus / Expert Rev Gastroenterol Hepatol 8:749~760
Galon J / 2006 / Type, density, and location of immune cells within human colorectal tumors predict clinical outcome / Science 313:1960~1964
Mosmann TR / 1986 / Two types of murine helper T cell clone. I. definition according to profiles of lymphokine activities and secreted proteins / J Immunol 136:2348~2357
Sakaguchi S / 2010 / FOXP3+ regulatory T cells in the human immune system / Nat Rev Immunol 10:490~500
O'Sullivan KE / 2014 / The role of inflammation in cancer of the esophagus / Expert Rev Gastroenterol Hepatol 8:749~760
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