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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 49 - 54 (6page)
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Previously, we reported that vitamin C facilitates the CpG demethylation of Foxp3 enhancer in CD4＋Foxp3＋ regulatory T cells (Tregs) by enhancing the activity of a DNA demethylase ten-eleven-translocation (Tet). However, it is not clear whether vitamin C affects other helper T cell lineages like T helper type 17 (Th17) cells which are related with Tregs. Here, we show that the expression of interleukin-17A (IL17) increases with the treatment of vitamin C but not with other antioxidants. Interestingly, the upregulation of IL17 was not accompanied by DNA demethylation in Il17 promoter and was independent of Tet enzymes. Rather, vitamin C reduced the trimethylation of histone H3 lysine 9 (H3K9me3) in the regulatory elements of the Il17 locus, and the effects of vitamin C were abrogated by knockdown of jumonji-C domain-containing protein 2 (jmjd2). These results suggest that vitamin C can affect the expression of IL17 by modulating the histone demethylase activity.
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참고문헌 (27)
참고문헌 신청
Blaschke K / 2013 / Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells / Nature 500 : 222 ~ 226
Chen J / 2013 / H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs / Nat Genet 45 : 34 ~ 42
Chowdhury R / 2011 / The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases / EMBO Rep 12 : 463 ~ 469
Ciofani M / 2012 / A validated regulatory network for Th17 cell specification / Cell 151 : 289 ~ 303
Dang EV / 2011 / Control of T(H)17/T(reg)balance by hypoxia-inducible factor 1 / Cell 146 : 772 ~ 784
Chen J / 2013 / H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs / Nat Genet 45 : 34 ~ 42
Chowdhury R / 2011 / The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases / EMBO Rep 12 : 463 ~ 469
Ciofani M / 2012 / A validated regulatory network for Th17 cell specification / Cell 151 : 289 ~ 303
Dang EV / 2011 / Control of T(H)17/T(reg)balance by hypoxia-inducible factor 1 / Cell 146 : 772 ~ 784
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