지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 640 - 646 (7page)
이용수
초록· 키워드
오류제보하기
Regulatory B cells, also well-known as IL-10-producing B cells, play a role in the suppression of inflammatory responses. However, the epigenetic modulation of regulatory B cells is largely unknown. Recent studies showed that the bromodomain and extra-terminal domain (BET) protein inhibitor JQ1 controls the expression of various genes involving cell proliferation and cell cycle. However, the role of BET proteins on development of regulatory B cells is not reported. In this study, JQ1 potently suppressed IL-10 expression and secretion in murine splenic and peritoneal B cells. While bromodomaincontaining protein 4 (BRD4) was associated with NF-κB on IL-10 promoter region by LPS stimulation, JQ1 interfered the interaction of BRD4 with NF-κB on IL-10 promoter. In summary, BRD4 is essential for toll like receptor 4 (TLR4)-mediated IL-10 expression, suggesting JQ1 could be a potential candidate in regulating IL-10-producing regulatory B cells in cancer.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Asangani IA / 2014 / Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer / Nature 510 : 278 ~ 282
DiLillo DJ / 2010 / B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer / Ann N Y Acad Sci 1183 : 38 ~ 57
Evans JG / 2007 / Novel suppressive function of transitional 2 B cells in experimental arthritis / J Immunol 178 : 7568 ~ 7878
Filippakopoulos P / 2010 / Selective inhibition of BET bromodomains / Nature 468 : 1067 ~ 1073
Gao F / 2015 / BRAD4 plays a critical role in germinal center response by regulating Bcl-6 and NF-?B activation / Cell Immunol 29
DiLillo DJ / 2010 / B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer / Ann N Y Acad Sci 1183 : 38 ~ 57
Evans JG / 2007 / Novel suppressive function of transitional 2 B cells in experimental arthritis / J Immunol 178 : 7568 ~ 7878
Filippakopoulos P / 2010 / Selective inhibition of BET bromodomains / Nature 468 : 1067 ~ 1073
Gao F / 2015 / BRAD4 plays a critical role in germinal center response by regulating Bcl-6 and NF-?B activation / Cell Immunol 29
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis
조직공학과 재생의학
2021 .10
-
The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis
한국생물공학회 학술대회
2021 .10
-
In vivo CRISPR Inhibition Screen Identifies BRD1 as Critical for Antitumor Activity of T Cells
한국생물공학회 학술대회
2023 .10
-
IL-33 promotes IL-10 production in macrophages: a role for IL-33 in macrophage foam cell formation
Experimental and Molecular Medicine
2017 .01
-
Bromodomain proteins: protectors against endogenous DNA damage and facilitators of genome integrity
Experimental and Molecular Medicine
2021 .09
-
Harnessing IL-2 for immunotherapy against cancer and chronic infection: A historical perspective and emerging trends
Experimental and Molecular Medicine
2024 .09
-
IL-30† (IL-27A): a familiar stranger in immunity, inflammation, and cancer
Experimental and Molecular Medicine
2021 .05
-
A neutrophil elastase-generated mature form of IL-33 is a potent regulator of endothelial cell activation and proliferative retinopathy
Experimental and Molecular Medicine
2024 .08
-
Interleukin-32: Frenemy in cancer?
BMB Reports
2019 .01
-
Entinostat, a histone deacetylase inhibitor, increases the population of IL-10+ regulatory B cells to suppress contact hypersensitivity
BMB Reports
2021 .10
-
BET inhibitors synergize with sunitinib in melanoma through GDF15 suppression
Experimental and Molecular Medicine
2023 .02
-
IL-17A exacerbates diabetic retinopathy by impairing Müller cell function via Act1 signaling
Experimental and Molecular Medicine
2016 .01
-
Cancer immunotherapy with T-cell targeting cytokines: IL-2 and IL-7
BMB Reports
2021 .01
-
IL-33 and IL-33-derived DC-based tumor immunotherapy
Experimental and Molecular Medicine
2024 .06
-
Locus of (IL-9) control: IL9 epigenetic regulation in cellular function and human disease
Experimental and Molecular Medicine
2024 .06
-
Interleukin-2/antibody complex expanding Foxp3＋ regulatory T cells exacerbates Th2-mediated allergic airway inflammation
BMB Reports
2019 .01
-
Ectopically Expressed Membrane-bound Form of IL-9 Exerts Immune-stimulatory Effect on CT26 Colon Carcinoma Cells
한국환경기술학회지
2017 .01
-
A novel IL-10-producing innate lymphoid cells (ILC10) in a contact hypersensitivity mouse model
BMB Reports
2016 .01
-
Inflammation-responsive Hydrogel for Local-immunomodulation via Epigenetic Modification of Macrophage in Wound Healing
한국고분자학회 학술대회 연구논문 초록집
2021 .04
-
Regulation of IL-6 signaling by miR-125a and let-7e in endothelial cells controls vasculogenic mimicry formation of breast cancer cells
BMB Reports
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0