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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 149 - 159 (11page)
- DOI
- 10.14776/piv.2021.28.e21
이용수
초록· 키워드
오류제보하기
Purpose: Antibiotic exposure during pregnancy may affect the fetus and newborn in many ways. This study investigated the impact of prenatal antibiotic exposure duration on neonatal outcomes in very preterm (VP) or very low birth weight (VLBW) infants.
Methods: From September 2015 to December 2020, preterm infants with gestational age less than 32 weeks or with a BW less than 1,500 g who were admitted to the neonatal intensive care unit, and their mothers were enrolled. Prenatal antibiotic exposure was defined as antibiotics received by mothers before delivery, and the patients were categorized into the non-antibiotic group, short-duration (SD; ≤7 days) group, or long-duration (LD; >7 days) groups.
Results: A total of 93 of 145 infants were exposed to prenatal antibiotics, among which 35 (37.6%) were in the SD group and 58 (62.4%) were in the LD group. Infants in the LD group had a significantly higher birth weight-for-gestational-age (BW/GA) Z-score than those in the non-antibiotic group, even after the adjustment for confounding factors (beta, 0.258; standard error, 0.149; P<0.001). Multivariate logistic regression analysis showed that prolonged prenatal antibiotic exposure was independently associated with death (adjusted odds ratio [aOR], 8.926; 95% confidence interval [CI], 1.482?53.775) and composite outcomes of death, necrotizing enterocolitis (NEC), and late-onset sepsis (LOS) (aOR, 2.375; 95% CI, 1.027?5.492).
Conclusions: Prolonged prenatal antibiotic exposure could increase the BW/GA Z-score and the risk of death and composite outcomes of death, NEC, and LOS in VP or VLBW infants.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Bookstaver PB / 2015 / A review of antibiotic use in pregnancy / Pharmacotherapy 35:1052~1062
Broe A / 2014 / Increasing use of antibiotics in pregnancy during the period 2000-2010: prevalence, timing, category, and demographics / BJOG 121:988~996
Committee on Practice Bulletins-Obstetrics / 2018 / ACOG practice bulletin No. 199: use of prophylactic antibiotics in labor and delivery / Obstet Gynecol 132:e103~e119
World Health Organization / 2015 / WHO recommendations for prevention and treatment of maternal peripartum infections / World Health Organization
2020 / Prelabor rupture of membranes: ACOG practice bulletin, number 217 / Obstet Gynecol 135:e80~e97
Broe A / 2014 / Increasing use of antibiotics in pregnancy during the period 2000-2010: prevalence, timing, category, and demographics / BJOG 121:988~996
Committee on Practice Bulletins-Obstetrics / 2018 / ACOG practice bulletin No. 199: use of prophylactic antibiotics in labor and delivery / Obstet Gynecol 132:e103~e119
World Health Organization / 2015 / WHO recommendations for prevention and treatment of maternal peripartum infections / World Health Organization
2020 / Prelabor rupture of membranes: ACOG practice bulletin, number 217 / Obstet Gynecol 135:e80~e97
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