지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background : Recently, several studies have shown that early-life antibiotic exposure is associated with the development of childhood overweight or obesity. However, study design and duration of exposure to antibiotics were different in some studies, resulting in different conclusions. Objective : To perform a systematic review and meta-analysis to investigate the association between early-life antibiotic exposure and development of overweight and obesity. Methods : A comprehensive search was performed to identify articles published prior to May 31, 2017 using PubMed and Cochrane Library. Eleven studies were finally included. Five of them were used for meta-analysis while the other six studies were used for qualitative analysis. Results : As a result of meta-analysis of five studies, early-life antibiotics exposure was significantly associated with the development of childhood overweight or obesity (OR=0.821; 95% CI: 0.766~0.880). Most studies used for qualitative analysis showed consistent results with meta-analysis Effects of gender and phase of exposure were also evaluated in detail in these studies. Conclusions : Overall, exposure to antibiotics within six years of age had a high risk of becoming overweight or obese in early childhood. Therefore, more careful considerations are needed when treating pediatric patients with antibiotics.
목차
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참고문헌 (23)
참고문헌 신청
Carlos Lifschitz / 2015 / Early Life Factors Influencing the Risk of Obesity / Pediatric Gastroenterology, Hepatology & Nutrition 18(4):217~223
Obesity and overweight World Health Organization
질병관리본부 / 2015 / 건강행태 및 만성질환 통계
건강보험심사평가원 / 2014 / 약제급여적정성평가
Azad M.B / 2017 / Early-Life Antibiotic Exposure, Gut Microbiota Development, and Predisposition to Obesity / Nestle Nutr Inst Workshop Ser 88:67~79
Obesity and overweight World Health Organization
질병관리본부 / 2015 / 건강행태 및 만성질환 통계
건강보험심사평가원 / 2014 / 약제급여적정성평가
Azad M.B / 2017 / Early-Life Antibiotic Exposure, Gut Microbiota Development, and Predisposition to Obesity / Nestle Nutr Inst Workshop Ser 88:67~79
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