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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 905 - 913 (9page)
- DOI
- 10.1007/s13770-021-00371-y
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초록· 키워드
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Background: The goal of this study was to create a biomaterial which combines concentrated growth factor (CGF) with an adipose-derived stem cell (ADSC) sheet to promote the repair of skull defects in rats.
METHODS: We determined the optimal concentration of CGF extract by investigating the effects of different concentrations (0, 5%, 10%, and 20%) on the proliferation and differentiation of ADSCs. Then we created a complex combining CGF with an ADSC sheet, and tested the effects on bone repair in four experimental rat groups: (A) control; (B) ADSC sheet; (C) CGF particles; (D) combination of CGF?+?ADSCs. Eight weeks after the procedure, osteogenesis was assessed by micro-CT and hematoxylin and eosin staining.
RESULTS: We found that the concentration of CGF extract that promoted optimal ADSC proliferation and differentiation in vitro was 20%. In turn, bone regeneration was promoted the most by the combination of CGF and ADSCs.
CONCLUSION: In this study, we determined the optimal ratio of CGF and ADSCs to be used in a biomaterial for bone regeneration. The resulting CGF/ADSCs complex promotes maxillofacial bone defect repair in rats.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Fennis JP / 2002 / Mandibular reconstruction : a clinical and radiographic animal study on the use of autogenous scaffolds and platelet-rich plasma / Int J Oral Maxillofac Surg 31:281~286
Park HC / 2016 / Early Bone formation at a femur defect using cgf and prf grafts in adult dogs : a comparative study / Implant Dent 25:387~393
Guilak F / 2006 / Clonal analysis of the differentiation potential of human adiposederived adult stem cells / J Cell physiol 206:229~237
Sheykhhasan M / 2019 / Human adiposederived stem cells with great therapeutic potential / Curr Stem Cell Res Ther 14:532~548
Lindroos B / 2011 / The potential of adipose stem cells in regenerative medicine / Stem Cell Rev Rep 7:269~291
Park HC / 2016 / Early Bone formation at a femur defect using cgf and prf grafts in adult dogs : a comparative study / Implant Dent 25:387~393
Guilak F / 2006 / Clonal analysis of the differentiation potential of human adiposederived adult stem cells / J Cell physiol 206:229~237
Sheykhhasan M / 2019 / Human adiposederived stem cells with great therapeutic potential / Curr Stem Cell Res Ther 14:532~548
Lindroos B / 2011 / The potential of adipose stem cells in regenerative medicine / Stem Cell Rev Rep 7:269~291
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