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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 243 - 251 (9page)
- DOI
- 10.1007/s13206-021-00023-2
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초록· 키워드
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The periosteal progenitor cell is suitable for bone tissue regeneration duo to its multipotent differentiation in osteogenesis and chondrogenesis. It was found that both physical and physiological stimuli can induce the differentiation of periosteal progenitor cells. However, the combined-effect of these two stimuli is not clear. The imitation of the nature movement?the cyclic tensile strain stimulation and the multiple growth factors producing cells?adipose-derived stem cells (ADSCs) were used as physical and physiological stimuli to investigate the differentiation of rabbit periosteal cells in this study. For this, a new membrane-type micro-system was invented to provide a simple examination platform for both factors in one single system. The specific rectangular culture chamber not only provided two different types of cells to grow separately but also delivered the single axial tensile strain generated in the micro-system to the cells. It was found that application of either physical or physiological stimuli alone was sufficient to induce the differentiation of periosteal cells. The low tensile strain (4, 5, 6 kPa) led to osteogenesis whereas high tensile strain (7 kPa) induced chondrogenesis. Even though the co-culture of ADSCs only induced osteogenic differentiation of periosteal cells, the co-culture of ADSCs to tensile strain treated periosteal cells further strengthened the osteogenic and chondrogenic differentiation potent in low and high tensile strain, respectively. This study provided the pre-clinical evidence of the stem cell therapy and continuous exercise in cell level bone tissue regeneration.
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참고문헌 (45)
참고문헌 신청
Simon, T. M. / 2003 / Cambium cell stimulation from surgical release of the periosteum / J. Orthop. Res 21:470~480
Arnsdorf, E. J. / 2009 / The periosteum as a cellular source for functional tissue engineering / Tissue Eng. Part A 15:2637~2642
Castro-Silva, I. I. / 2012 / Periosteal-derived cells for bone bioengineering: a promising candidate / Clin. Oral Implants Res 23:1238~1242
Ferretti, C. / 2014 / Periosteum derived stem cells for regenerative medicine proposals: boosting current knowledge / World J. Stem Cells 6:266
Ueno, T. / 2002 / Evaluation of osteogenic/chondrogenic cellular proliferation and diff erentiation in the xenogeneic periosteal graft / Ann. Plast. Surg 48:539~545
Arnsdorf, E. J. / 2009 / The periosteum as a cellular source for functional tissue engineering / Tissue Eng. Part A 15:2637~2642
Castro-Silva, I. I. / 2012 / Periosteal-derived cells for bone bioengineering: a promising candidate / Clin. Oral Implants Res 23:1238~1242
Ferretti, C. / 2014 / Periosteum derived stem cells for regenerative medicine proposals: boosting current knowledge / World J. Stem Cells 6:266
Ueno, T. / 2002 / Evaluation of osteogenic/chondrogenic cellular proliferation and diff erentiation in the xenogeneic periosteal graft / Ann. Plast. Surg 48:539~545
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