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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 465 - 474 (10page)
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초록· 키워드
오류제보하기
Bone defects are common disease requiring thorough treatments since the bone is a complex vascularized tissue that is composed of multiple cell types embedded within an intricate extracellular matrix (ECM). For past decades, tissue engineering using cells, proteins, and scaffolds has been suggested as one of the promising approaches for effective bone regeneration. Recently, many researchers have been interested in designing effective platform for tissue regeneration by orchestrating factors involved in microenvironment around tissues. Among factors affecting bone formation, vascularization during bone development and after minor insults via endochondral and intramembranous ossification is especially critical for the long-term support for functional bone. In order to create vascularized bone constructs, the interactions between human mesenchymal stem cells (MSCs) and endothelial cells (ECs) have been investigated using both direct and indirect co-culture studies. Recently, various culture methods including micropatterning techniques, three dimensional scaffolds, and microfluidics have been developed to create micro-engineered platforms that mimic the nature of vascularized bone formation, leading to the creation of functional bone structures. This review focuses on MSCs co-cultured with endothelial cells and microengineered platforms to determine the underlying interplay between co-cultured MSCs and vascularized bone constructs, which is ultimately necessary for adequate regeneration of bone defects.
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참고문헌 (98)
참고문헌 신청
Sharma B / 2004 / Engineering structurally organized cartilage and bone tissues / Ann Biomed Eng 32:148~159
Laurencin CT / 1999 / Tissue engineering: orthopedic applications / Annu Rev Biomed Eng 1:19~46
Santos MI / 2010 / Vascularization in bone tissue engineering: physiology, current strategies, major hurdles and future challenges / Macromol Biosci 10:12~27
Simmons CA / 2004 / Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells / Bone 35:562~569
Vo TN / 2012 / Strategies for controlled delivery of growth factors and cells for bone regeneration / Adv Drug Deliv Rev 64:1292~1309
Laurencin CT / 1999 / Tissue engineering: orthopedic applications / Annu Rev Biomed Eng 1:19~46
Santos MI / 2010 / Vascularization in bone tissue engineering: physiology, current strategies, major hurdles and future challenges / Macromol Biosci 10:12~27
Simmons CA / 2004 / Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells / Bone 35:562~569
Vo TN / 2012 / Strategies for controlled delivery of growth factors and cells for bone regeneration / Adv Drug Deliv Rev 64:1292~1309
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