지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 841 - 850 (10page)
- DOI
- 10.1007/s13770-021-00346-z
이용수
초록· 키워드
오류제보하기
BACKGROUND Ferroptosis is an iron-dependent, non-apoptotic programmed cell death. Cellular senescence contributes to aging and various age-related diseases through the expression of a senescence-associated secretory phenotype (SASP). Senescent cells are often resistant to ferroptosis via increased ferritin and impaired ferritinophagy. In this study, we investigated whether treatment with JQ1 could remove senescent cells by inducing ferroptosis.
METHODS Senescence of human dermal fibroblasts was induced in vitro by treating the cells with bleomycin. The senolytic effects of JQ1 were evaluated using a SA-β gal assay, annexin V analysis, cell counting kit-8 assay, and qRT-PCR. Ferroptosis following JQ1 treatment was evaluated with qRT-PCR and BODIPY staining.
RESULTS At a certain range of JQ1 concentrations, JQ1 treatment reduced the viability of bleomycin-treated cells (senescent cells) but did not reduce that of untreated cells (non-senescent cells), indicating that JQ1 treatment can selectively eliminate senescent cells. JQ1 treatment also decreased SASP expression only in senescent cells. Subsequently, JQ1 treatment reduced the expression of ferroptosis-resistance genes in senescent cells. JQ1 treatment induced lipid peroxidation in senescent cells but not in non-senescent cells.
CONCLUSION The data indicate that JQ1 can eliminate senescent cells via ferroptosis. This study suggests ferroptosis as a new mechanism of senolytic therapy.
목차
등록된 정보가 없습니다.
참고문헌 (53)
참고문헌 신청
Dixon SJ / 2012 / Ferroptosis : an iron-dependent form of nonapoptotic cell death / Cell 149:1060~1072
Li J / 2020 / Ferroptosis : past, present and future / Cell Death Dis 11:88
Sun Y / 2018 / Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells / Cell Death Dis 9:753
Friedmann Angeli JP / 2014 / Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice / Nat Cell Biol 16:1180~1191
Yagoda N / 2007 / RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels / Nature 447:864~868
Li J / 2020 / Ferroptosis : past, present and future / Cell Death Dis 11:88
Sun Y / 2018 / Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells / Cell Death Dis 9:753
Friedmann Angeli JP / 2014 / Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice / Nat Cell Biol 16:1180~1191
Yagoda N / 2007 / RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels / Nature 447:864~868
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