지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.9
- 수록면
- 382 - 392 (11page)
- DOI
- 10.1007/s13206-024-00142-6
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초록· 키워드
오류제보하기
Among human CD8 <sup>+</sup> T cells, senescent cells are marked by the expression of CD57. The frequency of senescent CD57<sup>+</sup> CD8 <sup>+</sup> T cells is significantly correlated with aging and age-associated disorders, and it can be measured by multi-color flow cytometry. However, multi-color flow cytometry presents challenges in terms of accessibility and requires significant resource allocation. Therefore, developing a rapid and straightforward method for quantifying CD57 <sup>+</sup> CD8<sup>+</sup> T cells remains a key challenge. This study introduces a microfluidic device composed of a PDMS microfluidic channel with a pre-modified glass substrate for anti-CD8 antibody immobilization. This design allows blood samples to flow through, enabling the selective capture of CD8 <sup>+</sup> T cells while minimizing the required blood sample volume. This technology enables accurate and reliable quantification of CD57<sup>+</sup> cells among captured CD8 <sup>+</sup> T cells through fluorescence image analysis. The ability of the device to easily quantify senescent CD57 <sup>+</sup> CD8<sup>+</sup>+ T cells is anticipated to contribute significantly to both immunological research and clinical applications.
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