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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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The purpose of this study is to investigate the changes in lipid proton (LP) composition according to the induced obese fatty liver and to use it as basic data for treatment and diagnosis of fatty liver in the future. The phantom study was conducted to identify differences between STEAM and PRESS Pulse sequences in LP concentration. A high-fat diet (60%) was administered to eight Sprague-Dawley rats to induce obesity and fatty liver disease. Baseline magnetic resonance imaging /spectroscopy data were obtained prior to the introduction of high-fat diet, and data acquisition experiments were performed after eight weeks using procedures identical to those used for baseline studies. The six lipid proton metabolites were calculated using LCModel software. The correlation between the fat percentage and each LP, revealed that the methylene protons at 1.3 ppm showed the highest positive correlation. The α-methylene protons to carboxyl and diallylic protons showed negative correlation with fat percentage. The methylene proton showed the highest increase in the LP; however, it constituted only 71.86% of the total LP concentration. The methylene proton plays a leading role in fat accumulation in liver parenchyma.
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참고문헌 (31)
참고문헌 신청
Adams LA / 2005 / The natural history of nonalcoholic fatty liver disease : A population-based cohort study / Gastroenterology 129(1):113~121
Marengo A / 2016 / Progression and natural history of nonalcoholic fatty liver disease in adults / Clin Liver Dis 20(2):313~324
Sakamoto M. / 2015 / 1. Clinincal diagnosis and medical care of liver disease, present situation and progress / Nihon Hoshasen Gijutsu Gakkai Zasshi 71(12):1265~1274
Han S / 2014 / Effect of pure microsteatosis on transplant outcomes after living donor liver transplantation : A matched case-control study / Liver Transpl 20(4):473~482
Kang BK / 2012 / Hepatic fat quantification : A prospective comparison of magnetic resonance spectroscopy and analysis methods for chemical-shift gradient echo magnetic resonance imaging with histologic assessment as the reference standard / Invest Radiol 47(6):368~375
Marengo A / 2016 / Progression and natural history of nonalcoholic fatty liver disease in adults / Clin Liver Dis 20(2):313~324
Sakamoto M. / 2015 / 1. Clinincal diagnosis and medical care of liver disease, present situation and progress / Nihon Hoshasen Gijutsu Gakkai Zasshi 71(12):1265~1274
Han S / 2014 / Effect of pure microsteatosis on transplant outcomes after living donor liver transplantation : A matched case-control study / Liver Transpl 20(4):473~482
Kang BK / 2012 / Hepatic fat quantification : A prospective comparison of magnetic resonance spectroscopy and analysis methods for chemical-shift gradient echo magnetic resonance imaging with histologic assessment as the reference standard / Invest Radiol 47(6):368~375
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