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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 178 - 186 (9page)
- DOI
- 10.17642/jcc.26.4.4
이용수
초록· 키워드
오류제보하기
In this study, we evaluated the anti-glycation activity and nephroprotective effects of Gelidium amansii 70% (v/v) ethanol extract (GAE) in mouse glomerular mesangial cells. GAE (1, 5, and 20 μg/mL) treatment significantly reduced advanced glycation end-products (AGEs) formation (p < 0.001), and inhibited AGEs formation up to 47.8% at 1 μg/mL GAE. In addition, GAE not only significantly inhibited the formation of AGEs-collagen cross-linking, but also showed the effect of breaking the already formed cross-links (p < 0.001). In particular, 20 μg/mL GAE (41.9%) exhibited similar breaking ability as ALT-711 (0.5 mg/mL, 33.7%) used as a positive control. Treatment of methylglyoxal (MGO), a precursor of AGEs, on mouse glomerular mesangial cells, increased intracellular MGO and AGEs accumulation, leading to increased reactive oxygen species (ROS) production and eventually induced renal cell apoptotic death. However, pre-treatment with the GAE, at 1, 5 and 20 μg/mL, reduce intracellular ROS production level to approximately 541.1-201.4%. Especially, pre-treatment of 20 μg/mL GAE significantly decreased intracellular MGO concentration (18.99 μg/mL) to a level similar to that of the non-treated group (16.67 μg/mL) (p 0.001). Moreover, it was confirmed by immunofluorescence analysis that GAE suppressed the AGEs accumulation in mouse glomerular mesangial cells. As a result, due to this effects of GAE, MGO-induced apoptotic cell death was dramatically reduced, proving that GAE has an ability in preventing AGEs-related diabetic nephropathy. Therefore, our results suggest that Gelidium amansii has high potential to be developed as a natural agent for diabetic complications with a low risk of side effects.
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참고문헌 (35)
참고문헌 신청
Shin, H. -J. / 2007 / The antimicrobial and growth inhibitory effect of Gelidium amansii L. fractions on cancer cell line / Korean Soci. Mar. Biotechnol 6:113~119
이부용 / 2020 / 개별인정원료 우뭇가사리추출물의 체지방 감소에 관한 기능성 고찰 / 식품과학과 산업 53(4):390~396
Yang, T. -H. / 2015 / Red algae (Gelidium amansii) reduces adposity via activation of lipolysis in rats with diabetes induced by streptozotocin-nicotinamide / J. Food Drug Anal 23:758~765
이윤경 / 2018 / Anti-inflammatory effects of Agar free-Gelidium amansii (GA) extracts in high-fat diet-induced obese mice / Nutrition Research and Practice 12(6):479~485
Kang, M. -C. / 2016 / Popular edible seaweed, Gelidium amansii prevents against diet-induced obesity / Food Chem. Toxicol 90:181~187
이부용 / 2020 / 개별인정원료 우뭇가사리추출물의 체지방 감소에 관한 기능성 고찰 / 식품과학과 산업 53(4):390~396
Yang, T. -H. / 2015 / Red algae (Gelidium amansii) reduces adposity via activation of lipolysis in rats with diabetes induced by streptozotocin-nicotinamide / J. Food Drug Anal 23:758~765
이윤경 / 2018 / Anti-inflammatory effects of Agar free-Gelidium amansii (GA) extracts in high-fat diet-induced obese mice / Nutrition Research and Practice 12(6):479~485
Kang, M. -C. / 2016 / Popular edible seaweed, Gelidium amansii prevents against diet-induced obesity / Food Chem. Toxicol 90:181~187
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