지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 219 - 228 (10page)
- DOI
- 10.5213/inj.2142004.002
이용수
초록· 키워드
오류제보하기
Purpose: To probe the effect and mechanism of androgen receptor antagonist MDV3100 on benign prostatic hyperplasia (BPH) of rats Methods: BPH rat model was induced by testosterone propionate. Then antagomir-miR-21-3p or agomir-miR-21-3p was injected into rats before MDV3100 treatment. The prostate index was measured by weighing the wet weight of the rat prostate.
The structural morphology of rat prostate was observed after hematoxylin & eosin staining. Immunohistochemistry was applied to evaluate the expression levels of Ki-6 and inflammatory cytokines (interleukin [IL]-6, IL-18, and tumor necrosis factor-α) in rat prostate tissues. Quantitative reverse transcription polymerase chain reaction was utilized for assessment of miR-21-3p expression, and Western blot for the performance of the phosphorylation levels of IKKα and p65.
Results: Injection of testosterone propionate caused increased prostate gland hyperplasia, heightened miR-21-3p level, and activated nuclear factor-kappa B (NF-κB) signaling pathway. Additionally, BPH was accompanied by inflammatory response, as evidenced by enhanced expressions of Ki-67 and inflammatory cytokines. MDV3100 exposure ameliorated BPH and suppressed miR-21-3p expression. Overexpression of miR-21-3p intensified BPH and inflammation level, while knockdown of miR-21-3p relieved BPH. The coeffect of miR-21-3p upregulation and MDV3100 subjection led to higher inflammatory response, elevated phosphorylation levels of IKKα and p65 than MDV3100 treatment alone.
Conclusions: Androgen receptor antagonist MDV3100 alleviates BPH and inflammatory response through miR-21-3p downregulation and NF-κB signaling pathway blockade.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Langan RC / 2019 / Benign prostatic hyperplasia / Prim Care 46:223~232
Rastrelli G / 2019 / Testosterone and benign prostatic hyperplasia / Sex Med Rev 7:259~271
Lee HN / 2013 / Effects of doxazosin on alpha 1-adrenergic receptors in prostates with benign prostatic hyperplasia / Low Urin Tract Symptoms 5:82~89
Alcaraz A / 2009 / Is there evidence of a relationship between benign prostatic hyperplasia and prostate cancer? Findings of a literature review / Eur Urol 55:864~873
Koohi Hosseinabadi O / 2020 / Benign prostatic hyperplasia treatment using plasmonic nanoparticles irradiated by laser in a rat model / Biomed Pharmacother 127:110118
Rastrelli G / 2019 / Testosterone and benign prostatic hyperplasia / Sex Med Rev 7:259~271
Lee HN / 2013 / Effects of doxazosin on alpha 1-adrenergic receptors in prostates with benign prostatic hyperplasia / Low Urin Tract Symptoms 5:82~89
Alcaraz A / 2009 / Is there evidence of a relationship between benign prostatic hyperplasia and prostate cancer? Findings of a literature review / Eur Urol 55:864~873
Koohi Hosseinabadi O / 2020 / Benign prostatic hyperplasia treatment using plasmonic nanoparticles irradiated by laser in a rat model / Biomed Pharmacother 127:110118
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Protective effect of Panicum dichotomiflorum in a rat model of testosterone-induced benign prostatic hyperplasia
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Hydrocotyle ramiflora attenuates benign prostatic hyperplasia in the rats
한국실험동물학회 학술발표대회 논문집
2021 .07
-
miR-196b-5p and miR-375 Expression in Gastric Cancer
대한임상종양학회 학술대회지
2016 .02
-
Regulation of Colonic Mucosal MicroRNA Expression via Multiple Targets in Visceral Hypersensitivity Rats by Tongxieyaofang
Yonsei Medical Journal
2018 .01
-
Characterization of LC3 and p62 on Rat Prostate Lobe in Benign Prostate Hyperplasia Animal Model
해부·생물인류학
2020 .12
-
Down Regulation of miR-34a and miR-143 May Indirectly Inhibit p53 in Oral Squamous Cell Carcinoma: a Pilot Study
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Circulating Plasma Micro RNAs in Patients with Major Depressive Disorder Treated with Antidepressants: A Pilot Study
PSYCHIATRY INVESTIGATION
2016 .01
-
Investigation of Dysregulation of Several MicroRNAs in Peripheral Blood of Schizophrenia Patients
Clinical Psychopharmacology and Neuroscience
2016 .01
-
Inflammatory Responses in a Benign Prostatic Hyperplasia Epithelial Cell Line (BPH-1) Infected with Trichomonas vaginalis
Parasites, Hosts and Diseases
2016 .04
-
Upregulation of miR-27b Facilitates Apoptosis of TNF-α-Stimulated Fibroblast-Like Synoviocytes
Yonsei Medical Journal
2019 .01
-
Expression of miR-221 and miR-18a in patients with hepatocellular carcinoma and its clinical significance
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2022 .06
-
A novel panel of serum miR-21/miR-155/miR-365 as a potential diagnostic biomarker for breast cancer
Annals of Surgical Treatment and Research
2017 .02
-
Community-based research on the benign prostatic hyperplasia prevalence rate in Korean rural area
Investigative and Clinical Urology
2015 .01
-
Urinary microRNA-1913 to microRNA-3659 expression ratio as a non-invasive diagnostic biomarker for prostate cancer
Investigative and Clinical Urology
2021 .01
-
MicroRNA Expression in Plasma of Esophageal Squamous Cell Carcinoma Patients
Journal of Korean Medical Science
2022 .06
-
Increased Expression of Herpes Virus-Encoded hsv1-miR-H18 and hsv2-miR-H9-5p in Cancer-Containing Prostate Tissue Compared to That in Benign Prostate Hyperplasia Tissu
International Neurourology Journal
2016 .01
-
MiR-675 Promotes the Growth of Hepatocellular Carcinoma Cells Through Cdc25A Pathway
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Combined Detection of Serum MiR-221-3p and MiR-122-5p Expression in Diagnosis and Prognosis of Gastric Cancer
Journal of Gastric Cancer
2019 .01
-
Black ginseng ameliorates testosterone-induced benign prostate hyperplasia in rats
한국실험동물학회 학술발표대회 논문집
2022 .01
-
MiR-92a-1-5p and miR-328-3p Are Up-Regulated in Skin of Female Pattern Hair Loss Patients
Annals of Dermatology
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0