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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제4호
- 발행연도
- 2018.7
- 수록면
- 391 - 398 (8page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.4.391
이용수
초록· 키워드
오류제보하기
The aim of this study was to evaluate the in vitro anti-inflammatory and utero-relaxant effect of α-bisabolol on the pregnant human myometrium. Samples from the pregnant human myometrium were used in functional tests to evaluate the inhibitory effect of α-bisabolol (560, 860, 1,200 and 1,860 μM) on spontaneous myometrial contractions. The intracellular cyclic adenosine monophosphate (cAMP) levels generated in response to α-bisabolol in human myometrial homogenates were measured by ELISA. The anti-inflammatory effect of α-bisabolol was determined through the measurement of two pro-inflammatory cytokines, tumor necrosis factor-α (TNFα) and interleukin (IL)-1β, and the anti-inflammatory cytokine IL-10, in pregnant human myometrial explants stimulated with lipopolysaccharide (LPS). Forskolin was used as a positive control to evaluate the cAMP and cytokine levels. α-Bisabolol was found to induce a significant inhibition of spontaneous myometrial contractions at the highest concentration level (p<0.05). α-Bisabolol caused a concentration-dependent decrease in myometrial cAMP levels (p<0.05) and a concentration-dependent decrease in LPS-induced TNFα and IL-1β production, while IL-10 production did not increase significantly (p>0.05). The anti-inflammatory and utero-relaxant effects induced by α-bisabolol were not associated with an increase in cAMP levels in pregnant human myometrial samples. These properties place α-bisabolol as a potentially safe and effective adjuvant agent in cases of preterm birth, an area of pharmacological treatment that requires urgent improvement.
목차
등록된 정보가 없습니다.
참고문헌 (46)
참고문헌 신청
Kemp MW / 2010 / Preterm birth, infection, and inflammation advances from the study of animal models / Reprod Sci 17:619~628
Burdet J / 2014 / Inflammation, infection and preterm birth / Curr Pharm Des 20:4741~4748
Víctor Manuel Muñoz-Pérez / 2017 / Relaxant and anti-inflammatory effect of two thalidomide analogs as PDE-4 inhibitors in pregnant rat uterus / The Korean Journal of Physiology & Pharmacology 21(4):429~437
Hubinont C / 2011 / Prevention of preterm labour: 2011 update on tocolysis / J Pregnancy 2011:941057
de Heus R / 2009 / Adverse drug reactions to tocolytic treatment for preterm labour: prospective cohort study / BMJ 338:b744
Burdet J / 2014 / Inflammation, infection and preterm birth / Curr Pharm Des 20:4741~4748
Víctor Manuel Muñoz-Pérez / 2017 / Relaxant and anti-inflammatory effect of two thalidomide analogs as PDE-4 inhibitors in pregnant rat uterus / The Korean Journal of Physiology & Pharmacology 21(4):429~437
Hubinont C / 2011 / Prevention of preterm labour: 2011 update on tocolysis / J Pregnancy 2011:941057
de Heus R / 2009 / Adverse drug reactions to tocolytic treatment for preterm labour: prospective cohort study / BMJ 338:b744
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