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초록· 키워드
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Objectives: The aim of this study is to investigate the anti-inflammatory effects of Ojeok-san and compare the therapeutic effects according to its formation.
Methods: We evaluated the anti-inflammatory effects of Ojeok-san using lipopolysaccharide (LPS) induced inflammatory animal model. Male SD rats were administered intra-orally with two different formulation types of Ojeok-san according to prescribed dosage. One hour later, to induce inflammatory responses, subsequent intra-peritoneal injection of LPS was conducted. After 5 hours later, serum TNF-α, IL-1β, IL-6 and PGE2 levels were measured by ELISA to assess the alteration of pro-inflammatory markers.
Results: In our experiment, regardless of its formation, administration of Ojeok-san decreased TNF-α, IL-1β, IL-6 and PGE2 level in serum. Furthermore, LPS-induced toxicity of liver and kidney was not detected by Ojeok-san administration.
Conclusions: The anti-inflammatory effect of Ojeok-san was shown in LPS-induced inflammatory model by decreasing pro-inflammatory markers, and there would be no significant difference in therapeutic effect between two formulation types of Ojeok-san.
Methods: We evaluated the anti-inflammatory effects of Ojeok-san using lipopolysaccharide (LPS) induced inflammatory animal model. Male SD rats were administered intra-orally with two different formulation types of Ojeok-san according to prescribed dosage. One hour later, to induce inflammatory responses, subsequent intra-peritoneal injection of LPS was conducted. After 5 hours later, serum TNF-α, IL-1β, IL-6 and PGE2 levels were measured by ELISA to assess the alteration of pro-inflammatory markers.
Results: In our experiment, regardless of its formation, administration of Ojeok-san decreased TNF-α, IL-1β, IL-6 and PGE2 level in serum. Furthermore, LPS-induced toxicity of liver and kidney was not detected by Ojeok-san administration.
Conclusions: The anti-inflammatory effect of Ojeok-san was shown in LPS-induced inflammatory model by decreasing pro-inflammatory markers, and there would be no significant difference in therapeutic effect between two formulation types of Ojeok-san.
목차
서론
재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (16)
참고문헌 신청
No YB / 1990 / A Literature Study on the Use of Ojeoksan / Journal of Herbal Formula Science 1(1):72~86
윤지연 / 2012 / 五積散의 臨床 活用에 대한 方劑學的 考察 / 대한한의학 방제학회지 20(2):153~164
김종대 / 2011 / 五積散이 Estradiol Valerate로 유발된 다낭성 난소 모델에서 난포의 성숙 및 NGF발현에 미치는 영향 / 대한한방부인과학회지 24(1):27~41
Kim JH / 2004 / Effects of Ojuck-san on Hyperlipidemia in Rats / Society of Preventive Korean Medicine 8(2):185~202
Moon YH / 1994 / Studies on the Anti-inflammatory and Analgesic Activities of Ohjuksan / Korean Journal of Pharmacognosy 25(3):258~263
윤지연 / 2012 / 五積散의 臨床 活用에 대한 方劑學的 考察 / 대한한의학 방제학회지 20(2):153~164
김종대 / 2011 / 五積散이 Estradiol Valerate로 유발된 다낭성 난소 모델에서 난포의 성숙 및 NGF발현에 미치는 영향 / 대한한방부인과학회지 24(1):27~41
Kim JH / 2004 / Effects of Ojuck-san on Hyperlipidemia in Rats / Society of Preventive Korean Medicine 8(2):185~202
Moon YH / 1994 / Studies on the Anti-inflammatory and Analgesic Activities of Ohjuksan / Korean Journal of Pharmacognosy 25(3):258~263
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