지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제3호
- 발행연도
- 2018.5
- 수록면
- 249 - 255 (7page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.3.249
이용수
초록· 키워드
오류제보하기
Echinacoside, an active compound in the herb Herba Cistanche, has been reported to inhibit glutamate release. In this study, we investigated the effects of echinacoside on spontaneous excitatory synaptic transmission changes induced by 4-aminopyridine (4-AP), by using the in vitro rat hippocampal slice technique and whole-cell patch clamp recordings from CA3 pyramidal neurons. Perfusion with echinacoside significantly suppressed the 4-AP-induced epileptiform activity in a concentration-dependent manner. Echinacoside reduced 4-AP-induced increase in frequency of spontaneous excitatory postsynaptic currents (sEPSCs) but it did not affect the amplitude of sEPSCs or glutamate-activated currents, implicating a presynaptic mechanism of action. Echinacoside also potently blocked sustained repetitive firing, which is a basic mechanism of antiepileptic drugs. These results suggest that echinacoside exerts an antiepileptic effect on hippocampal CA3 pyramidal neurons by simultaneously decreasing glutamate release and blocking abnormal firing synchronization.
Accordingly, our study provides experimental evidence that echinacoside may represent an effective pharmacological agent for treating epilepsy.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Brodie MJ / 2000 / Management of epilepsy in adolescents and adults / Lancet 356:323~329
Patsalos PN / 1999 / New antiepileptic drugs / Ann Clin Biochem 36:10~19
Loscher W / 2002 / Animal models of drug-resistant epilepsy / Novartis Found Symp 243:149~159
Rogawski MA / 2004 / The neurobiology of antiepileptic drugs / Nat Rev Neurosci 5:553~564
Sasaki K / 1995 / Anticonvulsant activity of bilobalide, a sesquiterpene in Ginkgo biloba L. leaves against chemical-induced and electroshock-induced convulsions in mice / Res Commun Biol Psychol Psychiatry 20:145~156
Patsalos PN / 1999 / New antiepileptic drugs / Ann Clin Biochem 36:10~19
Loscher W / 2002 / Animal models of drug-resistant epilepsy / Novartis Found Symp 243:149~159
Rogawski MA / 2004 / The neurobiology of antiepileptic drugs / Nat Rev Neurosci 5:553~564
Sasaki K / 1995 / Anticonvulsant activity of bilobalide, a sesquiterpene in Ginkgo biloba L. leaves against chemical-induced and electroshock-induced convulsions in mice / Res Commun Biol Psychol Psychiatry 20:145~156
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