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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 220 - 227 (8page)
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초록· 키워드
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Purpose: Modafinil is a wake-promoting agent that has been proposed to improve cognitive performance at the preclinical and clinical levels. Since there is insufficient evidence for modafinil to be regarded as a cognitive enhancer, the aim of this study was to investigate the effects of chronic modafinil administration on behavioral learning in healthy adult rats.
Methods: Y-maze training was used to assess learning performance, and the whole-cell patch clamp technique was used to assess synaptic transmission in pyramidal neurons of the hippocampal CA1 region of rats.
Results: Intraperitoneal administration of modafinil at 200 mg/kg or 300 mg/kg significantly improved learning performance.
Furthermore, perfusion with 1mM modafinil enhanced the frequency and amplitude of spontaneous postsynaptic currents and spontaneous excitatory postsynaptic currents in CA1 pyramidal neurons in hippocampal slices. However, the frequency and amplitude of spontaneous inhibitory postsynaptic currents in CA1 pyramidal neurons were inhibited by treatment with 1mM modafinil.
Conclusions: These results indicate that modafinil improves learning and memory in rats possibly by enhancing glutamatergic excitatory synaptic transmission and inhibiting GABAergic (gamma-aminobutyric acid-ergic) inhibitory synaptic transmission.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Beracochea D / 2001 / First evidence of a delay-dependent working memory-enhancing effect of modafinil in mice / Neuroreport 12 : 375 ~ 378
Beracochea D / 2002 / Improvement of learning processes following chronic systemic administration of modafinil in mice / Pharmacol Biochem Behav 73 : 723 ~ 728
Burgos H / 2010 / Effect of modafinil on learning performance and neocortical long-term potentiation in rats / Brain Res Bull 83 : 238 ~ 244
Didato G / 2009 / Treatment of narcolepsy / Expert Rev Neurother 9 : 897 ~ 910
Engber TM / 1998 / Brain regional substrates for the actions of the novel wake-promoting agent modafinil in the rat: comparison with amphetamine / Neuroscience 87 : 905 ~ 91
Beracochea D / 2002 / Improvement of learning processes following chronic systemic administration of modafinil in mice / Pharmacol Biochem Behav 73 : 723 ~ 728
Burgos H / 2010 / Effect of modafinil on learning performance and neocortical long-term potentiation in rats / Brain Res Bull 83 : 238 ~ 244
Didato G / 2009 / Treatment of narcolepsy / Expert Rev Neurother 9 : 897 ~ 910
Engber TM / 1998 / Brain regional substrates for the actions of the novel wake-promoting agent modafinil in the rat: comparison with amphetamine / Neuroscience 87 : 905 ~ 91
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