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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제5호
- 발행연도
- 2017.9
- 수록면
- 487 - 493 (7page)
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초록· 키워드
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The anterior cingulate cortex (ACC) is known for its role in perception of nociceptive signals and the associated emotional responses. Recent optogenetic studies, involving modulation of neuronal activity in the ACC, show that the ACC can modulate mechanical hyperalgesia. In the present study, we used optogenetic techniques to selectively modulate excitatory pyramidal neurons and inhibitory interneurons in the ACC in a model of chronic inflammatory pain to assess their motivational effect in the conditioned place preference (CPP) test. Selective inhibition of pyramidal neurons induced preference during the CPP test, while activation of parvalbumin (PV)-specific neurons did not. Moreover, chemogenetic inhibition of the excitatory pyramidal neurons alleviated mechanical hyperalgesia, consistent with our previous result. Our results provide evidence for the analgesic effect of inhibition of ACC excitatory pyramidal neurons and a prospective treatment for chronic pain.
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참고문헌 (33)
참고문헌 신청
Bush G / 2000 / Cognitive and emotional influences in anterior cingulate cortex / Trends Cogn Sci 4:215~222
Allman JM / 2001 / The anterior cingulate cortex. The evolution of an interface between emotion and cognition / Ann N Y Acad Sci 935:107~117
Shenhav A / 2013 / The expected value of control : an integrative theory of anterior cingulate cortex function / Neuron 79:217~240
Einarsson EÖ / 2015 / Systems reconsolidation reveals a selective role for the anterior cingulate cortex in generalized contextual fear memory expression / Neuropsychopharmacology 40:480~487
Frankland PW / 2004 / The involvement of the anterior cingulate cortex in remote contextual fear memory / Science 304:881~883
Allman JM / 2001 / The anterior cingulate cortex. The evolution of an interface between emotion and cognition / Ann N Y Acad Sci 935:107~117
Shenhav A / 2013 / The expected value of control : an integrative theory of anterior cingulate cortex function / Neuron 79:217~240
Einarsson EÖ / 2015 / Systems reconsolidation reveals a selective role for the anterior cingulate cortex in generalized contextual fear memory expression / Neuropsychopharmacology 40:480~487
Frankland PW / 2004 / The involvement of the anterior cingulate cortex in remote contextual fear memory / Science 304:881~883
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