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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제1호
- 발행연도
- 2018.1
- 수록면
- 101 - 110 (10page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.1.101
이용수
초록· 키워드
오류제보하기
In this study, we aimed to investigate the neuroprotective effects of caffeic acid phenethyl ester (CAPE), an active component of propolis purified from honeybee hives, on photothrombotic cortical ischemic injury in mice. Permanent focal ischemia was achieved in the medial frontal and somatosensory cortices of anesthetized male C57BL/6 mice by irradiation of the skull with cold light laser in combination with systemic administration of rose bengal. The animals were treated with CAPE (0.5-5 mg/kg, i.p.) twice 1 and 6 h after ischemic insult. CAPE significantly reduced the infarct size as well as the expression of tumor necrosis factor-α, hypoxiainducible factor-1α, monocyte chemoattractant protein-1, interleukin-1α, and indoleamine 2,3-dioxygenase in the cerebral cortex ipsilateral to the photothrombosis.
Moreover, it induced an increase in heme oxygenase-1 immunoreactivity and interleukin- 10 expression. These results suggest that CAPE exerts a remarkable neuroprotective effect on ischemic brain injury via its anti-inflammatory properties, thereby providing a benefit to the therapy of cerebral infarction.
목차
등록된 정보가 없습니다.
참고문헌 (63)
참고문헌 신청
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Benjamin EJ / 2017 / Heart disease and stroke statistics-2017 update: a report from the American Heart Association / Circulation 135:e146~e603
National Institute of Neurological Disorders / 1995 / Tissue plasminogen activator for acute ischemic stroke / N Engl J Med 333:1581~1587
Lambrinos A / 2016 / Mechanical thrombectomy in acute ischemic stroke: a systematic review / Can J Neurol Sci 43:455~460
Denes A / 2010 / Inflammation and brain injury: acute cerebral ischaemia, peripheral and central inflammation / Brain Behav Immun 24:708~723
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