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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 146 - 146 (1page)
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Stroke is the global cause of death and permanent disability. Chlorogenic acid has antioxidant, and anti-apoptotic properties. In the current study, we investigated antioxidant and anti-apoptotic properties of chlorogenic acid against middle cerebral artery occlusion (MCAO)-induced cerebral ischemia in adult rats. Rats were injected intraperitoneally with chlorogenic acid (30 mg/kg) or vehicle 2 h after ischemia. After 24 h, cerebral cortex tissues were separated and reactive oxygen species (ROS) and malondialdehyde (MDA) assay, and histopathological analysis were performed. Two-dimensional gel electrophoresis and mass spectrometry techniques were performed to identify protein changes by chlorogenic acid. Results showed a significant increase in both ROS and MDA levels, histopathological lesions, and a high increase in terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells in the ischemic cerebral cortex. Conversely, chlorogenic acid-treatment significantly reduced these changes in M ... 전체 초록 보기
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