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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제3호
- 발행연도
- 2017.5
- 수록면
- 293 - 300 (8page)
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초록· 키워드
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Prostaglandin D2 (PGD2) may act against myocardial ischemia? reperfusion (I/R) injury and play an anti-inflammatory role in the heart. Although the effect of PGD2 in regulation of ANP secretion of the atrium was reported, the mechanisms involved are not clearly identified. The aim of the present study was to investigate whether PGD2 can regulate ANP secretion in the isolated perfused beating rat atrium, and its underlying mechanisms. PGD2 (0.1 to 10 mM) significantly increased atrial ANP secretion concomitantly with positive inotropy in a dosedependent manner. Effects of PGD2 on atrial ANP secretion and mechanical dynamics were abolished by AH-6809 (1.0 mM) and AL-8810 (1.0 mM), PGD2 and prostaglandin F2a (PGF2a) receptor antagonists, respectively. Moreover, PGD2 clearly upregulated atrial peroxisome proliferator-activated receptor gamma (PPARg) and the PGD2 metabolite 15-deoxy-D12,14-PGJ2 (15d-PGJ2, 0.1 mM) dramatically increased atrial ANP secretion. Increased ANP secretions induced by PGD2 and 15d-PGJ2 were completely blocked by the PPARg antagonist GW9662 (0.1 mM). PD98059 (10.0 mM) and LY294002 (1.0 mM), antagonists of mitogen-activated protein kinase (MAPK)/ extracellular signal-regulated kinase (ERK) and phosphatidylinositol-3-kinase (PI3K)/ protein kinase B (Akt) signaling, respectively, significantly attenuated the increase of atrial ANP secretion by PGD2. These results indicated that PGD2 stimulated atrial ANP secretion and promoted positive inotropy by activating PPARg in beating rat atria. MAPK/ERK and PI3K/Akt signaling pathways were each partially involved in regulating PGD2-induced atrial ANP secretion.
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참고문헌 (24)
참고문헌 신청
Kalra BS / 2012 / Efficacy of metabolic modulators in ischemic heart disease : an overview / J Clin Pharmacol 52:292~305
Ryu SK / 2012 / Phospholipase A2 enzymes, high-dose atorvastatin, and prediction of ischemic events after acute coronary syndromes / Circulation 125:757~766
Gross GJ / 2005 / Cytochrome P450 and arachidonic acid metabolites : role in myocardial ischemia/reperfusion injury revisited / Cardiovasc Res 68:18~25
Qiu H / 2012 / Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemia / Cardiovasc Res 95:336~345
Ricciotti E / 2011 / Prostaglandins and inflammation / Arterioscler Thromb Vasc Biol 31:986~1000
Ryu SK / 2012 / Phospholipase A2 enzymes, high-dose atorvastatin, and prediction of ischemic events after acute coronary syndromes / Circulation 125:757~766
Gross GJ / 2005 / Cytochrome P450 and arachidonic acid metabolites : role in myocardial ischemia/reperfusion injury revisited / Cardiovasc Res 68:18~25
Qiu H / 2012 / Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemia / Cardiovasc Res 95:336~345
Ricciotti E / 2011 / Prostaglandins and inflammation / Arterioscler Thromb Vasc Biol 31:986~1000
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