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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 411 - 416 (6page)
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Background/Aims: To investigate the expression of Toll-like receptor 4 (TLR4) in the pancreases of rats with acute necrotizing pancreatitis (ANP) and any changes upon treatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor κB (NF-κB), as well as to determine the relationship between TLR4 and NF-κB in ANP pathogenesis. Methods: A total of 72 SD rats were randomly divided into three groups, namely, the control (sham-operation), ANP, and ANP with PDTC pretreatment groups. The PDTC-pretreated group was intraperitoneally injected with PDTC at a dose of 100 mg/kg 1 hour before the induction of ANP. The expressions of TLR4 and NF-κB in pancreatic tissue were evaluated by immunohistochemistry and Western blot analysis. The mRNA levels of cytokines tumor necrosis factor α, interleukin (IL)-1β, and IL-6 were measured by reverse transcription polymerase chain reaction. Results: The expressions of TLR4, NF-κB, and cytokine (NF-κB target) genes in the pancreatic tissue increased more significantly in the ANP groups than in the sham-operation group at 3, 6, and 12 hours. Pretreatment with PDTC alleviated the inflammatory activation in the pancreas with ANP, causing a significant decrease in the expressions of TLR4, NF-κB, and cytokine genes in the pancreatic tissue. Conclusions: The expressions of TLR4 and NF-κB were increased in the pancreases of rats with ANP. PDTC not only inhibits NF-κB but also suppresses the expression of TLR4 and downregulates the expression of the related cytokine genes.
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참고문헌 (14)
참고문헌 신청
Aho HJ / 1980 / Experimental pancreatitis in the rat. Sodium taurocholate-induced acute haemorrhagic pancreatitis / Scand J Gastroenterol 15 : 411 ~ 416
Algul H / 2002 / Acute experimental pancreatitis and NF-kappaB/Rel activation / Pancreatology 2 : 503 ~ 509
Giakoustidis A / 2010 / Dissecting the stress activating signaling pathways in acute pancreatitis / Hepatogastroenterology 57 : 653 ~ 656
Gordon S / 2002 / Pattern recognition receptors: doubling up for the innate immune response / Cell 111 : 927 ~ 930
Huang H / 2013 / Activation of nuclear factor-kappaB in acinar cells increases the severity of pancreatitis in mice / Gastroenterology 144 : 202 ~ 210
Algul H / 2002 / Acute experimental pancreatitis and NF-kappaB/Rel activation / Pancreatology 2 : 503 ~ 509
Giakoustidis A / 2010 / Dissecting the stress activating signaling pathways in acute pancreatitis / Hepatogastroenterology 57 : 653 ~ 656
Gordon S / 2002 / Pattern recognition receptors: doubling up for the innate immune response / Cell 111 : 927 ~ 930
Huang H / 2013 / Activation of nuclear factor-kappaB in acinar cells increases the severity of pancreatitis in mice / Gastroenterology 144 : 202 ~ 210
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