지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Preimplantation genetic diagnosis (PGD) is a technique to examine genetic disease or chromosome abnormalities in single cell biopsied from embryos before implantation to uterus. It allows achieving normal pregnancy by transfer of unaffected embryos. The main indications are single gene disorders and recurrent miscarriage related to chromosome aberration and it has advantages to avoid termination of pregnancy or miscarriages in couples with high risk. PGD is also widely applied for aneuploidy screening in assisted reproduction to improve the outcome in infertile patients such as advanced maternal age, although its efficacy still needs to be established. Furthermore, the application of PGD has expanded to other indications, such as late onset-diseases with genetic predisposition and human leukocyte antigen typing for stem cell transplantation. With the advances of molecular diagnostic technologies using single cells, such as fluorescent in situ hybridization, multiplex polymerase chain reaction, fluorescent polymerase chain reaction, linkage analysis, whole genome amplification, array comparative genomic hybridization (array comparative genomic hybridization), and next generation sequencing, PGD can provide more comprehensive and reliable diagnosis.
목차
등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Hardy K / 1990 / Human preimplantation development in vitro is not adversely affected by biopsy at the 8-cell stage / Hum Reprod 5:708~714
Handyside AH / 1990 / Preg-nancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification / Nature 344:768~770
Staessen C / 1999 / Clinical experience of sex determination by fluorescent in-situ hybridization for preim-plantation genetic diagnosis / Mol Hum Reprod 5:382~389
Goossens V / 2012 / ESHRE PGD Consortium data collection XI : cycles from January to December 2008 with pregnancy follow-up to October 2009 / Hum Reprod 27:1887~1911
de Boer KA / 2004 / Moving to blastocyst biopsy for preimplantation genetic diagnosis and single embryo transfer at Sydney IVF / Fertil Steril 82:295~298
Handyside AH / 1990 / Preg-nancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification / Nature 344:768~770
Staessen C / 1999 / Clinical experience of sex determination by fluorescent in-situ hybridization for preim-plantation genetic diagnosis / Mol Hum Reprod 5:382~389
Goossens V / 2012 / ESHRE PGD Consortium data collection XI : cycles from January to December 2008 with pregnancy follow-up to October 2009 / Hum Reprod 27:1887~1911
de Boer KA / 2004 / Moving to blastocyst biopsy for preimplantation genetic diagnosis and single embryo transfer at Sydney IVF / Fertil Steril 82:295~298
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