Ameliorative effects of atractylodin on intestinal inflammation and co-occurring dysmotility in both constipation and diarrhea prominent rats

Changchun Yu; Yuan Lin; Yong-jian Xiong; Da-peng Chen; Yanli Li; Bin Xu; Zeyao Tang; Chunling Jiang; Li Wang

추천

검색

자료유형: 학술저널

저자정보: Changchun Yu (Dalian Medical University) Yuan Lin (Dalian Medical University) Yong-jian Xiong (Dalian Medical University) Da-peng Chen (Dalian Medical University) Yanli Li (Dalian Medical University) Bin Xu (Dalian Medical University) Zeyao Tang (Dalian Medical University) Chunling Jiang (Dalian Medical University) Li Wang (Dalian Medical University)

저널정보: 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제1호

발행연도: 2017.1

수록면: 1 - 9 (9page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Intestinal disorders often co-occur with inflammation and dysmotility. However, drugs which simultaneously improve intestinal inflammation and cooccurring dysmotility are rarely reported. Atractylodin, a widely used herbal medicine, is used to treat digestive disorders. The present study was designed to characterize the effects of atractylodin on amelioration of both jejunal inflammation and the co-occurring dysmotility in both constipation-prominent (CP) and diarrheaprominent (DP) rats. The results indicated that atractylodin reduced proinflammatory cytokines TNF-α, IL-1β, and IL-6 in the plasma and inhibited the expression of inflammatory mediators iNOS and NF-kappa B in jejunal segments in both CP and DP rats. The results indicated that atractylodin exerted stimulatory effects and inhibitory effects on the contractility of jejunal segments isolated from CP and DP rats respectively, showing a contractile-state-dependent regulation. Atractylodininduced contractile-state-dependent regulation was also observed by using rat jejunal segments in low and high contractile states respectively (5 pairs of low/ high contractile states). Atractylodin up-regulated the decreased phosphorylation of 20 kDa myosin light chain, protein contents of myosin light chain kinase (MLCK), and MLCK mRNA expression in jejunal segments of CP rats and down-regulated those increased parameters in DP rats. Taken together, atractylodin alleviated rat jejunal inflammation and exerted contractile-state-dependent regulation on the contractility of jejunal segments isolated from CP and DP rats respectively, suggesting the potential clinical implication for ameliorating intestinal inflammation and co-occurring dysmotility.

#Atractylodin Constipation Contractile-state-dependent regulation Diarrhea Inflammation Jejunal contractility

참고문헌 (53)

참고문헌 신청

Xia YG / 2013 / Species classification and quality assessment of cangzhu(atractylodis rhizoma)by high-performance liquid chromatography and chemometric methods / J Anal Methods Chem 2013:497532

Committee SP / 2010 / Pharmacopoeia of the people’s republic of China / China Medical Science Press

Zhang Y / 2012 / Determination of atractylodin in rat plasma by HPLC-UV method and its application to a Pharmacokinetic study / Journal of Liquid Chromatography &Related Technologies 35:778~787

Huo Y / 2014 / Determination of(4E, 6E, 12E)-tetradecatriene-8, 10-diyne-1, 3-diyl diacetate in rat plasma and tissues by HPLC-UV method and their application to a pharmacokinetic and tissue distribution study / J Anal Methods Chem 2014:249061

Su TM / 2008 / A research review of chemical constituents and medical function of Rhizoma atractylodis macrocepha1 Lae / Journal of Guiyang University(Natural Sciences)

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!