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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제4호
- 발행연도
- 2017.7
- 수록면
- 407 - 413 (7page)
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초록· 키워드
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Vascular reactivity can be influenced by the vascular region, animal age, and pathologies present. Prostaglandins (produced by COX-1 and COX-2) play an important role in the contractile response to phenylephrine in the abdominal aorta of young rats. Although these COXs are found in many tissues, their distribution and role in vascular reactivity are not clear. At a vascular level, they take part in the homeostasis functions involved in many physiological and pathologic processes (e.g., arterial pressure and inflammatory processes). The aim of this study was to analyze changes in the contractile response to phenylephrine of thoracic/abdominal aorta and the coronary artery during aging in rats. Three groups of rats were formed and sacrificed at three distinct ages: prepubescent, young and old adult. The results suggest that there is a higher participation of prostanoids in the contractile effect of phenylephrine in pre-pubescent rats, and a lower participation of the same in old rats. Contrarily, there seems to be a higher participation of prostanoids in the contractile response of the coronary artery of older than pre-pubescent rats.
Considering that the changes in the expression of COX-2 were similar for the three age groups and the two tissues tested, and that expression of COX-1 is apparently greater in older rats, COX-1 and COX-2 may lose functionality in relation to their corresponding receptors during aging in rats.
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참고문헌 (23)
참고문헌 신청
Castillo-Hernandez MC / 2010 / The influence of constitutive COX-2 in smooth muscle tissue on the contractile effect of phenylephrine in the rat abdominal aorta / Front Biosci(Elite Ed) 2:441~448
Kähönen M / 1998 / Influence of gender on control of arterial tone in experimental hypertension / Am J Physiol 275:H15~H22
Pairet M / 1996 / Distinct isoforms(COX-1 and COX-2)of cyclooxygenase : possible physiological and therapeutic implications / Fundam Clin Pharmacol 10:1~17
Smith WL / 1996 / Prostaglandin endoperoxide H synthases-1and-2 / Adv Immunol 62:167~215
Zidar N / 2007 / Expression of cyclooxygenase-1 and cyclooxygenase-2 in the normal human heart and in myocardial infarction / Cardiovasc Pathol 16:300~304
Kähönen M / 1998 / Influence of gender on control of arterial tone in experimental hypertension / Am J Physiol 275:H15~H22
Pairet M / 1996 / Distinct isoforms(COX-1 and COX-2)of cyclooxygenase : possible physiological and therapeutic implications / Fundam Clin Pharmacol 10:1~17
Smith WL / 1996 / Prostaglandin endoperoxide H synthases-1and-2 / Adv Immunol 62:167~215
Zidar N / 2007 / Expression of cyclooxygenase-1 and cyclooxygenase-2 in the normal human heart and in myocardial infarction / Cardiovasc Pathol 16:300~304
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