지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.8
- 수록면
- 240 - 249 (10page)
- DOI
- 10.5125/jkaoms.2020.46.4.240
이용수
초록· 키워드
오류제보하기
Objectives: Although the side effects of radiation therapy vary from mucositis to osteomyelitis depending on the dose of radiation therapy, to date, an experimental animal model has not yet been proposed. The aim of this study was to develop an animal model for assessing complications of irradiated bone, especially to quantify the dose of radiation needed to develop a rat model.Materials and Methods: Sixteen Sprague-Dawley rats aged seven weeks with a mean weight of 267.59 g were used. Atraumatic extraction of a right mandibular first molar was performed. At one week after the extraction, the rats were randomized into four groups and received a single dose of external radiation administered to the right lower jaw at a level of 14, 16, 18, or 20 Gy, respectively. Clinical alopecia with body weight changes were compared and bony volumetric analysis with micro-computed tomography (CT), histologic analysis with H&E were performed. Results: The progression of the skin alopecia was different depending on the irradiation dose. Micro-CT parameters including bone volume, bone volume/tissue volume, bone mineral density, and trabecular spaces, showed no significant differences. The progression of osteoradionecrosis (ORN) along with that of inflammation, fibrosis, and bone resorption, was found with increased osteoclast or fibrosis in the radiated group. As the radiation dose increases, osteoclast numbers begin to decrease and osteoclast tends to increase. Osteoclasts respond more sensitively to the radiation dose, and osteoblasts are degraded at doses above 18 Gy.Conclusion: A standardized animal model clinically comparable to ORN of the jaw is a valuable tool that can be used to examine the pathophysiol-ogy of the disease and trial any potential treatment modalities. We present a methodology for the use of an experimental rat model that incorporates a guideline regarding radiation dose.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
김성민 / 2015 / 악골골수염 처치를 위한 조직공학적 접근 / 조직공학과 재생의학 12(1):11~26
Støre G / 2000 / Mandibular osteoradionecrosis : clinical behaviour and diagnostic aspects / Clin Otolaryngol Allied Sci 25:378~384
Costa DA / 2016 / New perspectives on the conservative management of osteoradionecrosis of the mandible : a literature review / Head Neck 38:1708~1716
Marx RE / 1983 / Osteoradionecrosis: a new concept of its pathophysiology / J Oral Maxillofac Surg 41:283~288
Delanian S / 2004 / The radiation-induced fibroatrophic process : therapeutic perspective via the antioxidant pathway / Radiother Oncol 73:119~131
Støre G / 2000 / Mandibular osteoradionecrosis : clinical behaviour and diagnostic aspects / Clin Otolaryngol Allied Sci 25:378~384
Costa DA / 2016 / New perspectives on the conservative management of osteoradionecrosis of the mandible : a literature review / Head Neck 38:1708~1716
Marx RE / 1983 / Osteoradionecrosis: a new concept of its pathophysiology / J Oral Maxillofac Surg 41:283~288
Delanian S / 2004 / The radiation-induced fibroatrophic process : therapeutic perspective via the antioxidant pathway / Radiother Oncol 73:119~131
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