지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1,019 - 1,030 (12page)
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초록· 키워드
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Purpose Radiation-induced oral mucositis limits delivery of high-dose radiation to targeted cancers. Therefore, it is necessary to develop a treatment strategy to alleviate radiation-induced oral mucositis during radiation therapy. We previously reported that inhibiting reactive oxygen species (ROS) generation suppresses autophagy. Irradiation induces autophagy, suggesting that antioxidant treatment may be used to inhibit radiation-induced oral mucositis. Materials and Methods We determined whether treatment with N-acetyl cysteine (NAC) could attenuate radiation-induced buccal mucosa damage in vitro and in vivo. The protective effects of NAC against oral mucositis were confirmed by transmission electron microscopy and immunocytochemistry. mRNA and protein levels of DNA damage and autophagy-related genes were measured by quantitative real-time polymerase chain reaction and western blot analysis, respectively. Results Rats manifesting radiation-induced oral mucositis showed decreased oral intake, loss of body weight, and low survival rate. NAC intake slightly increased oral intake, body weight, and the survival rate without statistical significance. However, histopathologic characteristics were markedly restored in NAC-treated irradiated rats. LC3B staining of rat buccal mucosa revealed that NAC treatment significantly decreased the number of radiation-induced autophagic cells. Further, NAC inhibited radiation-induced ROS generation and autophagy signaling. In vitro, NAC treatment significantly reduced the expression of NRF2, LC3B, p62, and Beclin-1 in keratinocytes compared with that after radiation treatment. Conclusion NAC treatment significantly inhibited radiation-induced autophagy in keratinocytes and rat buccal mucosa and may be a potentially safe and effective option for the prevention of radiation-induced buccal mucosa damage.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Sankaranarayanan R / 1998 / Head and neck cancer : a global perspective on epidemiology and prognosis / Anticancer Res 18:4779~4786
Epstein JB / 2000 / The correlation between epidermal growth factor levels in saliva and the severity of oral mucositis during oropharyngeal radiation therapy / Cancer 89:2258~2265
Leborgne JH / 1998 / Corticosteroids and radiation mucositis in head and neck cancer : a double-blind placebo-controlled randomized trial / Radiother Oncol 47:145~148
Rosenthal DI / 2009 / Strategies for managing radiation-induced mucositis in head and neck cancer / Semin Radiat Oncol 19:29~34
Hille A / 2003 / Effect of keratinocyte growth factor on the proliferation, clonogenic capacity and colony size of human epithelial tumour cells in vitro / Int J Radiat Biol 79:119~128
Epstein JB / 2000 / The correlation between epidermal growth factor levels in saliva and the severity of oral mucositis during oropharyngeal radiation therapy / Cancer 89:2258~2265
Leborgne JH / 1998 / Corticosteroids and radiation mucositis in head and neck cancer : a double-blind placebo-controlled randomized trial / Radiother Oncol 47:145~148
Rosenthal DI / 2009 / Strategies for managing radiation-induced mucositis in head and neck cancer / Semin Radiat Oncol 19:29~34
Hille A / 2003 / Effect of keratinocyte growth factor on the proliferation, clonogenic capacity and colony size of human epithelial tumour cells in vitro / Int J Radiat Biol 79:119~128
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