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논문 기본 정보

자료유형
학술저널
저자정보
Chang, Hsien Pin (Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Yonsei University College of Medicine) Cho, Jae Ho (Department of Radiation Oncology, Yonsei University College of Medicine) Lee, Won Jai (Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Yonsei University College of Medicine) Roh, Hyun (Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Yonsei University College of Medicine) Lee, Dong Won (Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Yonsei University College of Medicine)
저널정보
대한성형외과학회 Archives of plastic surgery : APS Archives of plastic surgery : APS 제45권 제5호
발행연도
2018.1
수록면
403 - 410 (8page)

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Background Radiation-induced skin injury is a dose-limiting complication of radiotherapy. To investigate this problem and to develop a framework for making decisions on treatment and dose prescription, a murine model of radiation-induced skin injury was developed. Methods The dorsal skin of the mice was isolated, and irradiation was applied at single doses of 15, 30, and 50 Gy. The mice were followed for 12 weeks with serial photography and laser Doppler analysis. Sequential skin biopsy samples were obtained and subjected to a histological analysis, immunostaining against transforming growth factor beta (TGF-${\beta}$), and Western blotting with Wnt-3 and ${\beta}$-catenin. Increases in the levels of TGF-${\beta}$, Wnt, and ${\beta}$-catenin were detected after irradiation. Results All tested radiation doses caused progressive dermal thickening and fibrosis. The cause of this process, however, may not be radiation alone, as the natural course of wound healing may elicit a similar response. The latent appearance of molecular and histological markers that induce fibrosis in the 15 Gy group without causing apparent gross skin injuries indicates that 15 Gy is an appropriate dose for characterizing the effects of chronic irradiation alone. Thus, this model best mimics the patterns of injury that occur in human subjects. Conclusions This animal model can be used to elucidate the gross and molecular changes that occur in radiation-induced skin injury and provides an effective platform for studying this adverse effect without complicating the process of wound healing.
#Radiation #Wound and injuries #Skin #Mice

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참고문헌 (16)

참고문헌 신청
Collen EB / 2006 / Acute effects of radiation treatment: skin reactions / Can Vet J 47:931~935 google schola Yarnold J / 2010 / Pathogenetic mechanisms in radiation fibrosis / Radiother Oncol 97:149~161 google schola Kim JW / 2013 / Development of a porcine skin injury model and characterization of the dose-dependent response to high-dose radiation. / J Radiat Res 54:823~831 google schola Seaton M / 2015 / Porcine models of cutaneous wound healing / ILAR J 56:127~138 google schola Williams JP / 2010 / Animal models for medical countermeasures to radiation exposure / Radiat Res 173:557~578 google schola

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