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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제55권 제5호
- 발행연도
- 2021.9
- 수록면
- 338 - 348 (11page)
- DOI
- 10.4132/jptm.2021.07.26
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초록· 키워드
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Background: Preoperative locoregional treatment (LRT) for hepatocellular carcinoma (HCC) often induces intratumoral necrosis without affecting the overall tumor size, and residual viable tumor size (VTS) on imaging is an important clinical parameter for assessing post-treatment response. However, for surgical specimens, it is unclear whether the VTS would be more relevant to prognosis compared to total tumor size (TTS).Methods: A total of 142 surgically resected solitary HCC cases were retrospectively reviewed. The TTS and VTS were assessed by applying the modified Response Evaluation Criteria in Solid Tumors method to the resected specimens, and correlated with the clinicopathological features and survival.Results: As applying VTS, 13/142 cases (9.2%) were down-staged to ypT1a. Although the survival analysis results for overall survival according to TTS or VTS were similar, VTS was superior to predict disease-free survival (DFS; p = .023) compared to TTS (p = .08). In addition, multivariate analysis demonstrated VTS > 2 cm to be an independent predictive factor for decreased DFS (p = .001). In the subpopulation of patients with LRT (n = 54), DFS in HCCs with TTS or VTS > 2 cm were significantly shorter than those with TTS or VTS ≤ 2 cm (p = .047 and p = .001, respectively). Interestingly, HCCs with TTS > 2 cm but down-staged to VTS ≤ 2 cm after preoperative LRT had similar survival to those with TTS ≤ 2 cm.Conclusions: Although the prognostic impact of tumor size was similar regardless of whether TTS or VTS was applied, reporting VTS may help to increase the number of candidates for surgery in HCC patients with preoperative LRT.
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참고문헌 (30)
참고문헌 신청
Bray F / 2018 / Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 68:394~424
Kamarajah SK / 2018 / Critical evaluation of the American Joint Commission on Cancer(AJCC)8th edition staging system for patients with Hepatocellular Carcinoma(HCC) : a Surveillance, Epidemiology, End Results(SEER)analysis / J Surg Oncol 117:644~650
Chun YS / 2018 / 8th edition of the AJCC cancer staging manual : pancreas and hepatobiliary cancers / Ann Surg Oncol 25:845~847
European Association for the Study of the Liver / 2012 / EASL-EORTC clinical practice guidelines : management of hepatocellular carcinoma / J Hepatol 56:908~943
Yau T / 2014 / Development of Hong Kong Liver Cancer staging system with treatment stratification for patients with hepatocellular carcinoma / Gastroenterology 146:1691~1700
Kamarajah SK / 2018 / Critical evaluation of the American Joint Commission on Cancer(AJCC)8th edition staging system for patients with Hepatocellular Carcinoma(HCC) : a Surveillance, Epidemiology, End Results(SEER)analysis / J Surg Oncol 117:644~650
Chun YS / 2018 / 8th edition of the AJCC cancer staging manual : pancreas and hepatobiliary cancers / Ann Surg Oncol 25:845~847
European Association for the Study of the Liver / 2012 / EASL-EORTC clinical practice guidelines : management of hepatocellular carcinoma / J Hepatol 56:908~943
Yau T / 2014 / Development of Hong Kong Liver Cancer staging system with treatment stratification for patients with hepatocellular carcinoma / Gastroenterology 146:1691~1700
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