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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.8
- 수록면
- 937 - 945 (9page)
- DOI
- 10.1007/s13258-021-01082-3
이용수
초록· 키워드
오류제보하기
Background The folate metabolism that converts homocysteine to methionine is closely related to the accumulation of homocysteine. Increased homocysteine levels lead to an impaired antithrombotic function of the vascular endothelium and uterine-placental circulation, resulting in abnormal pregnancy outcomes. Previous studies have reported that gene polymorphisms in folate metabolism are associated with the development of preterm birth (PTB) in various populations.
Objective we performed a case?control study to evaluate the association between fve polymorphisms in folate metabolic genes (MTHFR, MTR, MTRR, TCN2) and PTB.
Methods In this study, a total of 254 subjects were analyzed (111 patients with PTB and 143 women at≥38 weeks of gestation). Genotype and allele frequency diferences between patients and control groups and the Hardy?Weinberg equilibrium were assessed using a Chi-square test. For evaluation indicators, odds ratios (ORs) of 95% confdence intervals (CI) were estimated. In addition, we analyzed the combined genotype frequencies of SNPs of folate-metabolizing genes to measure gene?gene interactions for PTB.
Results Our results showed that the MTR rs1805087 GG (p=0.031), and TCN2 rs1801198 CG genotype (OR 0.53, 95% CI 0.288?0.980, p=0.042) were signifcantly associated with PTB. The MTHFR rs4846049 AA showed a marginal trend toward signifcance (OR 0.15, 95% CI 0.018?1.205, p=0.041). In particular, the combined genotypes, including MTHFR rs1537514 CC?MTRR rs1801394 GG, MTHFR rs1537514 CC?TCN2 rs1801198 CG, and MTR rs1805087 AA?TCN2 rs1801198 CG, have signifcant interactions with PTB (OR 0.49, 95% CI 0.248?0.992, p<0.05).
Conclusion The polymorphisms of folate metabolic genes may have a genetic association with the development of PTB in Korean women. A larger sample set and functional studies are required to further elucidate our fndings.
목차
등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Bailey LB / 1999 / Folate metabolism and requirements / J Nutr 129(4):779~782
Beck S / 2010 / The worldwide incidence of preterm birth : a systematic review of maternal mortality and morbidity / Bull World Health Organ 88(1):31~38
Blencowe H / 2012 / National, regional, and worldwide estimates of preterm birth rates in the year 2010 with timetrends since 1990 for selected countries : a systematic analysis and implication / Lancet 379(9832):2162~2172
Cai D / 2010 / Association of polymorphisms in folate metabolic genes and prostate cancer risk : a case-control study in a Chinese population / J Genet 89(2):263~267
Chen J / 2016 / Association of methylenetetrahydrofolate reductase(MTHFR)C677T polymorphism with preterm delivery and placental abruption : a systematic review and meta-analysis / Acta Obstet Gynecol Scand 95(2):157~165
Beck S / 2010 / The worldwide incidence of preterm birth : a systematic review of maternal mortality and morbidity / Bull World Health Organ 88(1):31~38
Blencowe H / 2012 / National, regional, and worldwide estimates of preterm birth rates in the year 2010 with timetrends since 1990 for selected countries : a systematic analysis and implication / Lancet 379(9832):2162~2172
Cai D / 2010 / Association of polymorphisms in folate metabolic genes and prostate cancer risk : a case-control study in a Chinese population / J Genet 89(2):263~267
Chen J / 2016 / Association of methylenetetrahydrofolate reductase(MTHFR)C677T polymorphism with preterm delivery and placental abruption : a systematic review and meta-analysis / Acta Obstet Gynecol Scand 95(2):157~165
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