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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 689 - 699 (11page)
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Gene polymorphisms involved in homocysteine- methionine pathway result in hyperhomocysteinemia, a predisposing condition to several diseases. Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate and homocysteine metabolism. The two known functional polymorphisms of MTHFR gene, 677C>T and 1298A>C have been implicated in a variety of multifactorial diseases: cardio-cerebrovascular and neurodegenerative disorders, autoimmune diseases, birth defects, diabetes, neuropsychiatric disorders, cancer and renal disease. C667T, and to a lesser extent A1298C polymorphisms, have been also reported to have a pharmacogenetic role in predicting drug toxicity in cancer and rheumatoid arthritis treatment. We review here the principal effects of the MTHFR gene variations in different clinical conditions.
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참고문헌 (62)
참고문헌 신청
Akchurin OM / 2015 / Update on inflammation in chronic kidney disease / Blood Purif 39:84~92
Alizadeh S / 2016 / C667T and A1298C polymorphisms of methylene tetrahydrofolate reductase gene and susceptibility to myocardial infarction: a systematic review and meta-analysis / Int J Cardiol 217:99~108
Angeline T / 2007 / MTHFR gene polymorphisms, B-vitamins and hyperhomocystinemia in young and middle-aged acute myocardial infarction patients / Exp Mol Pathol 82:227~233
Bagley PJ / 1998 / A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells / Proc Natl Acad Sci USA 95:13217~13220
Biswas A / 2009 / Homocystine levels, polymorphisms and the risk of ischemic stroke in young Asian Indians / J Stroke Cerebrovasc Dis 18:103~110
Alizadeh S / 2016 / C667T and A1298C polymorphisms of methylene tetrahydrofolate reductase gene and susceptibility to myocardial infarction: a systematic review and meta-analysis / Int J Cardiol 217:99~108
Angeline T / 2007 / MTHFR gene polymorphisms, B-vitamins and hyperhomocystinemia in young and middle-aged acute myocardial infarction patients / Exp Mol Pathol 82:227~233
Bagley PJ / 1998 / A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells / Proc Natl Acad Sci USA 95:13217~13220
Biswas A / 2009 / Homocystine levels, polymorphisms and the risk of ischemic stroke in young Asian Indians / J Stroke Cerebrovasc Dis 18:103~110
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Combined effect of folate and adiposity on homocysteine in children at three years of age
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Crystal Structure and Sequence Analysis of N5, N10-Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase Enzyme from Porphyromonas gingivalis
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