Prognostic value of preoperative neutrophil-to-lymphocyte ratio in histological variants of non-muscle-invasive bladder cancer

Deng-xiong Li; Xiao-ming Wang; Yin Tang; Yu-bo Yang; Dechao Feng; Ao Li; Fa-cai Zhang; Yun-jin Bai; Ping Han

doi:https://doi.org/10.4111/icu.20210278

Prognostic value of preoperative neutrophil-to-lymphocyte ratio in histological variants of non-muscle-invasive bladder cancer

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Type: Academic journal

Author: Deng-xiong Li (Department of Urology Institute of Urology West China Hospital Sichuan University Chengdu China) Xiao-ming Wang (Department of Urology Institute of Urology West China Hospital Sichuan University Chengdu China) Yin Tang (Sichuan University) Yu-bo Yang (Department of Urology Institute of Urology West China Hospital Sichuan University Chengdu China)

Journal: The Korean Urology Association Investigative and Clinical Urology Investigative and Clinical Urology Vol.62 No.6 KCI Accredited Journals

Published: 2021.11

Pages: 641 - 649 (9page)

DOI: https://doi.org/10.4111/icu.20210278

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Prognostic value of preoperative neutrophil-to-lymphocyte ratio in histological variants of non-muscle-invasive bladder cancer

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Purpose: Many studies identified that the preoperative neutrophil-to-lymphocyte ratio (PNLR) was associated with patient prognosis in non-muscle-invasive bladder cancer (NMIBC). We hypothesized that PNLR could be prognostic in patients with histological variants of NMIBC (VH-NMIBC). Materials and Methods: This retrospective study included patients with VH-NMIBC admitted at our center between January 2009 and May 2019. The best cut-off value of NLR was measured by the receiver operating characteristic curve and Youden index. The Kaplan-Meier method and Cox proportional hazard regression models were employed to evaluate the association between PNLR and disease prognosis, including recurrence-free survival (RFS), progression-free survival (PFS), cancer-specific survival (CSS), and overall survival (OS). Results: A total of 243 patients with VH-NMIBC were enrolled in our study. According to the Kaplan-Meier method results, patients with PNLR ≥2.2 were associated with poor RFS (p<0.001), PFS (p<0.001), CSS (p<0.001), and OS (p<0.001). Multivariable analyses indicated that PNLR ≥ 2.2 was an independent prognostic factor of RFS (hazard ratio [HR], 2.11; 95% confidence interval [CI, 1.57?1.83; p<0.001), PFS (HR, 2.34; 95% CI, 1.70?3.21; p<0.001), CCS (HR, 2.87; 95% CI, 1.96?4.18; p< 0.001), and OS (HR, 2.83; 95% CI, 1.96?4.07; p<0.001). Conclusions: This study identified that PNLR ≥2.2 was usually associated with a poor prognosis for patients with VH-NMIBC.

#Bladder cancer #Histology #Lymphocyte #Neutrophil #Prognosis

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Deng-xiong Li

Affiliation Department of Urology Institute of Urology West China Hospital Sichuan University Chengdu China