지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제47권 제6호
- 발행연도
- 2017.11
- 수록면
- 583 - 591 (9page)
이용수
초록· 키워드
오류제보하기
The current investigation aimed to enhance the dissolution rate and mask the bitter taste of levofloxacin by developing pharmaceutical cocrystals using stearic acid and saccharin sodium as coformers. The developed cocrystals were characterized by Fourier transform infrared spectroscopy, which showed the formation of a regular carboxylic acid homosynthon in 1:1 ratio of levofloxacinstearic acid and carboxylic acid- imide heterosynthon in 2:1 ratio of levofloxacin-saccharin sodium. The existence of the drug in a new crystalline form in the developed cocrystals was confirmed by solid state characterization. The dissolution studies of the developed cocrystals in simulated gastric fluid (pH 1.2) showed significant improvement of the drug dissolution rate (%min?1) from L-ST1 (7.8 ± 0.1) and L-SA2 (7.2 ± 0.4) cocrystals compared to supplied levofloxacin (4.4 ± 0.3). The taste masking ability of L-ST1 and L-SA2 was determined by conducting dissolution studies at salivary pH 6.6 and the results showed a very low drug release of 6.6 ± 0.6% from L-ST1 compared to supplied levofloxacin (64.5 ± 1.5%) and L-SA2 (55.1 ± 1.5%) in 5 min.
This study demonstrates that pharmaceutical cocrystals of levofloxacin with stearic acid at 1:1 ratio enhanced the dissolution rate and masked the bitter taste of levofloxacin whereas saccharin sodium has showed only improved dissolution.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Aakeröy CB / 2006 / Cyanophenyloximes:reliable and versatile tools for hydrogen-bond directed supramolecular synthesis of co-crystals / Cryst Growth Des 6:1033~1042
Agarwal R / 2000 / Studies of ion-exchange resin complex of chloroquine phosphate / Drug Dev Ind Pharm 26:773~776
Ayenew Z / 2009 / Trends in pharmaceutical taste masking technologies: a patent review / Recent Pat Drug Deliv Formul 3:26~39
Basavoju S / 2008 / Indomethacin-saccharin cocrystal: design, synthesis and preliminary pharmaceutical characterization / Pharm Res 25:530~541
Deng Y / 2011 / The effects of levofloxacin on rabbit anterior cruciate ligament cells in vitro / Toxicol Appl Pharmacol 257:67~73
Agarwal R / 2000 / Studies of ion-exchange resin complex of chloroquine phosphate / Drug Dev Ind Pharm 26:773~776
Ayenew Z / 2009 / Trends in pharmaceutical taste masking technologies: a patent review / Recent Pat Drug Deliv Formul 3:26~39
Basavoju S / 2008 / Indomethacin-saccharin cocrystal: design, synthesis and preliminary pharmaceutical characterization / Pharm Res 25:530~541
Deng Y / 2011 / The effects of levofloxacin on rabbit anterior cruciate ligament cells in vitro / Toxicol Appl Pharmacol 257:67~73
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
단일 대학병원 폐렴 입원환자의 Levofloxacin 사용 적정성 평가
병원약사회지
2020 .01
-
Real-world evidence of levofloxacin prophylaxis in elderly patients with newly diagnosed multiple myeloma who received bortezomib, melphalan, and prednisone regimen
Blood Research
2022 .03
-
Association between the Levofloxacin Plasma Concentration and Neurological Adverse Events in an Elderly Patient
Journal of Clinical Neurology
2019 .01
-
Pharmacokinetic profiles of levofloxacin after intravenous, intramuscular and subcutaneous administration to rabbits (Oryctolagus cuniculus)
Journal of Veterinary Science
2020 .03
-
Synthesis, solid state characterization and antifungal activity of ketoconazole cocrystals
Journal of Pharmaceutical Investigation
2018 .09
-
Efficacy of Levofloxacin-Based Third-Line Therapy for the Eradication of Helicobacter pylori in Peptic Ulcer Disease
Gut and Liver
2017 .01
-
High Efficacy of Levofloxacin-Dexlansoprazole-Based Quadruple Therapy as a First Line Treatment for Helicobacter pylori Eradication in Thailand
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Impact of Marital Dissolution Timing and Duration on Self-Rated Health of Marriage Immigrants in Single-Person Households in South Korea
지역사회간호학회지
2025 .03
-
A new phantom to evaluate the tissue dissolution ability of endodontic irrigants and activating devices
Restorative Dentistry and Endodontics
2020 .01
-
Management of Antibiotic-Resistant Helicobacter pylori Infection: Perspectives from Vietnam
Gut and Liver
2019 .01
-
플루오로퀴놀론 항생제의 QT 간격 연장 발생률과 위험인자 분석
병원약사회지
2023 .05
-
Severe Thrombocytopenia in a Patient with COVID-19
Infection and Chemotherapy
2020 .01
-
Steep improvement in dissolution profile of ezetimibe through co-inclusion in urea
Journal of Pharmaceutical Investigation
2016 .08
-
하수처리 공정 내 미세입자 거동 평가: 응집, 침전, 용해
환경독성보건학회 심포지엄 및 학술대회
2022 .05
-
Modified sprouted rice for modulation of curcumin crystallinity and dissolution enhancement by solid dispersion
Journal of Pharmaceutical Investigation
2019 .01
-
Efficacy of Magnesium Trihydrate of Ursodeoxycholic Acid and Chenodeoxycholic Acid for Gallstone Dissolution: A Prospective Multicenter Trial
Gut and Liver
2015 .01
-
수환경에서 산화아연나노입자의 응집과 용해 특성 연구 : 자연유기물과 인산염의 영향
환경독성보건학회 심포지엄 및 학술대회
2016 .06
-
Sodium Intake, Blood Pressure and Cardiovascular Disease
Korean Circulation Journal
2020 .01
-
Micronization of a poorly water-soluble drug, fenofibrate, via supercritical-fluid-assisted spray-drying
Journal of Pharmaceutical Investigation
2022 .05
-
Serotype Distribution and Antimicrobial Resistance of Invasive and Noninvasive Streptococcus pneumoniae Isolates in Korea between 2014 and 2016
Annals of Laboratory Medicine
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0