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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제47권 제5호
- 발행연도
- 2017.9
- 수록면
- 383 - 394 (12page)
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초록· 키워드
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pH sensitive nanocarriers have showed the tumor targeted drug delivery and release by enhanced permeability and retention effect and responsiveness of acidic pH conditions of the solid tumors. The protonation and deprotonation of the nanocarriers including pH sensitive polyelectrolytes has been considered as a major mechanism, resulting in substantial conformational change in response to marginal change in the tumor pH conditions.
Considering the biocompatible properties for pharmaceutical applications, poly(amino acid) showed low polymer toxicity and the formation of versatile systems for advanced antitumor therapeutic effects. In here, recent researches using cationic (histidine, lysine, and arginine), anionic (aspartic acid and glutamic acid), and zwitterionic amino acid were summarized. Furthermore, pH sensitive nanogels with unique functionality and other pH sensitive polymers were briefly described. pH sensitive nanogels showed reversible drug release by pH cyclization minimizing drug loss and enhancing drug release. In the future, nonspherical pH sensitive nanocarriers would be anticipated to improve the therapeutic effect by long circulation and stealth effect by low phagocytosis.
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등록된 정보가 없습니다.
참고문헌 (143)
참고문헌 신청
Ahmad Z / 2014 / Cisplatin loaded methoxy poly (ethylene glycol)-block-Poly (l-glutamic acid-co-l-phenylalanine) nanoparticles against human breast cancer cell / Macromol Biosci 14:1337~1345
Ahmad Z / 2016 / Methoxy poly (ethylene glycol)-block-poly (glutamic acid)-graft-6-(2-nitroimidazole)hexyl amine nanoparticles for potential hypoxiaresponsive delivery of doxorubicin / J Biomater Sci Polym Ed 27:40~54
Ahn J / 2015 / Antibody fragment-conjugated polymeric micelles incorporating platinum drugs for targeted therapy of pancreatic cancer / Biomaterials 39:23~30
Al-Jamal KT / 2013 / Cationic poly-l-lysine dendrimer complexes doxorubicin and delays tumor growth in vitro and in vivo / ACS Nano 7:1905~1917
Allen C / 1999 / Nano-engineering block copolymer aggregates for drug delivery / Colloids Surf B 16:3~27
Ahmad Z / 2016 / Methoxy poly (ethylene glycol)-block-poly (glutamic acid)-graft-6-(2-nitroimidazole)hexyl amine nanoparticles for potential hypoxiaresponsive delivery of doxorubicin / J Biomater Sci Polym Ed 27:40~54
Ahn J / 2015 / Antibody fragment-conjugated polymeric micelles incorporating platinum drugs for targeted therapy of pancreatic cancer / Biomaterials 39:23~30
Al-Jamal KT / 2013 / Cationic poly-l-lysine dendrimer complexes doxorubicin and delays tumor growth in vitro and in vivo / ACS Nano 7:1905~1917
Allen C / 1999 / Nano-engineering block copolymer aggregates for drug delivery / Colloids Surf B 16:3~27
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