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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제47권 제4호
- 발행연도
- 2017.7
- 수록면
- 365 - 371 (7page)
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초록· 키워드
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Hypertension is a major risk factor for cardiovascular diseases and is known to contribute to complications, such as atherosclerosis and diabetes. The aim of this study was to investigate the possible synergistic effects of candesartan, an angiotensin II receptor blocker (ARB), and ramipril, an angiotensin-converting enzyme inhibitor (ACEI), in lowering high blood pressure in spontaneously hypertensive rats (SHRs). SHRs were given oral candesartan (1.53 mg/kg/day) and ramipril (0.48 mg/kg/day) for 2 weeks. The combination of candesartan and ramipril improved systolic blood pressure (SBP), mean arterial pressure (MAP), and heart rate (HR) significantly compared with monotherapy. Additionally, combined treatment with candesartan (3.06 mg/kg/day) and ramipril (0.96 mg/ kg/day) significantly decreased cuff-induced neointima hyperplasia and media thickness in C57BL/6 mice. In oral glucose tolerance tests (OGTTs), the combination of candesartan and ramipril significantly controlled blood glucose levels within 2 h after glucose loading in low-dose (38 mg/ kg, i.p.) streptozotocin-treated Wistar rats. Taken together, the present study suggests that combination therapy with candesartan and ramipril may be a beneficial therapeutic strategy for the treatment of hypertensive patients with related complications, such as atherosclerosis and diabetes.
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참고문헌 (35)
참고문헌 신청
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Akishita M / 2000 / Inflammation influences vascular remodeling through AT2receptor expression and signaling / Physiol Genomics 2:13~20
Atlas SA / 2007 / The renin-angiotensin aldosterone system: pathophysiological role and pharmacologic inhibition / J Manag Care Pharm 13:S9~S20
Carey RM / 2003 / Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation / Endocr Rev 24:261~271
Conen D / 2007 / Blood pressure and risk of developing type 2 diabetes mellitus: the Women’s Health Study / Eur Heart J 28:2937~2943
Akishita M / 2000 / Inflammation influences vascular remodeling through AT2receptor expression and signaling / Physiol Genomics 2:13~20
Atlas SA / 2007 / The renin-angiotensin aldosterone system: pathophysiological role and pharmacologic inhibition / J Manag Care Pharm 13:S9~S20
Carey RM / 2003 / Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation / Endocr Rev 24:261~271
Conen D / 2007 / Blood pressure and risk of developing type 2 diabetes mellitus: the Women’s Health Study / Eur Heart J 28:2937~2943
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