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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제50권 제6호
- 발행연도
- 2020.1
- 수록면
- 573 - 581 (9page)
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초록· 키워드
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Purpose Polypharmacy has been an important strategy for the management of hypertension. The aim of this study was to investigate the effect of combined treatment of losartan with ramipril on hypertension, myocardial infarction and vascular remodeling in disease animal models. Methods In 8-telemetered spontaneous hypertensive rats (SHRs) orally treated with various doses of drugs or vehicle by cross-over protocol, systolic blood pressure (SBP), mean arterial pressure (MAP) and heart rate (HR) were measured. The infarct size was measured in rats subjected to 30 min occlusion of the left anterior descending coronary artery (LAD) followed by 150 min reperfusion in myocardial ischemia/reperfusion (MI/R) rats injected drugs or vehicle once through femoral vein 15 min before inducing ischemia. The neointima formation and DNA synthesis in intima and media layer of the blood vessels were measured in cuff-induced vascular injury mice orally treated with drugs for 2 weeks. Results As compared with single treatment, the combination therapy of both drugs significantly decreased SBP and MAP without significant reflex tachycardia. The combined treatment of both drugs significantly increased the expression of endothelial nitric oxide synthase (eNOS) in coronary arterial tissues including area at occlusion. The combination therapy significantly decreased the thickness of vascular media layer and the number of bromodeoxyuridine (BrdU)-positive cells in both intima and media. Conclusion The present data suggest that the combination therapy with fixed doses of losartan and ramipril may exert greater BP-lowering effects with protection against myocardial infarction and vascular remodeling.
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참고문헌 (45)
참고문헌 신청
Alexander RW / 1995 / Theodore Cooper Memorial Lecture. Hypertension and the pathogenesis of atherosclerosis. Oxidative stress and the mediation of arterial inflammatory response: a new perspective / Hypertension 25:155~161
Arauz-Pacheco C / 2003 / Treatment of hypertension in adults with diabetes / Diabetes Care 26(Suppl 1):S80~S82
Avdeev SN / 2018 / Combination therapy is a new standard for treatment of pulmonary arterial hypertension / Ter Arkh 90:72~80
Azar RR / 2019 / Global impact of the new European and American hypertension guidelines : a perspective from Lebanon / J Clin Hypertens(Greenwich) 21:684~686
Bath PM / 2018 / Blood pressure in acute stroke : to treat or not to treat : that is still the question / Stroke 49:1784~1790
Arauz-Pacheco C / 2003 / Treatment of hypertension in adults with diabetes / Diabetes Care 26(Suppl 1):S80~S82
Avdeev SN / 2018 / Combination therapy is a new standard for treatment of pulmonary arterial hypertension / Ter Arkh 90:72~80
Azar RR / 2019 / Global impact of the new European and American hypertension guidelines : a perspective from Lebanon / J Clin Hypertens(Greenwich) 21:684~686
Bath PM / 2018 / Blood pressure in acute stroke : to treat or not to treat : that is still the question / Stroke 49:1784~1790
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