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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제47권 제2호
- 발행연도
- 2017.3
- 수록면
- 85 - 94 (10page)
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초록· 키워드
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In recent decade, antimicrobial resistance is a serious international concern resulted by misuse of antibiotics.
Some dangerous pathogenic strains such as Methicillin- resistant Staphylococcus aureus are resistant to the wide range of conventional antibiotics. Antimicrobial peptides (AmPs) are remarkable antibacterial drugs, which can be used instead of conventional antibiotics due to their membrane targeting activity especially against both gramnegative and gram-positive multidrug-resistant strains of pathogenic bacteria. Target delivery of AmPs is necessary because of short half-life and relative toxicity against healthy cells. Polysaccharide-based nanostructured carriers such as nanoparticles and layer-by-layer thin films are widely used due to their biocompatibility, stimuli-responsive properties, and strong affinity to bond with proteins and peptides. In this review, we focus on some prominent polysaccharide-based AmP delivery systems and describe some advantage and disadvantage of each carrier. We also introduce some novel AmP nanocarriers due to the two main strategies of combat against antibacterial resistance.
Among these novel carriers, polysaccharide-based nanogels have incredible properties such as high loading capacity, stimuli responsive release behavior, simple largescale production, and thermodynamically stability, which could be a promising candidate for controlled release of AmPs.
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참고문헌 (75)
참고문헌 신청
Arora D / 2016 / An update on polysaccharide-based nanomaterials for antimicrobial applications / Appl Microbiol Biotechnol 100:2603~2615
Azevedo HS / 2015 / Biomimetic supramolecular designs for the controlled release of growth factors in bone regeneration / Adv Drug Deliv Rev 94:63~76
Baier G / 2013 / Enzyme responsive hyaluronic acid nanocapsules containing polyhexanide and their exposure to bacteria to prevent infection / Biomacromolecules 14:1103~1112
Bi L / 2011 / Carbohydrate nanoparticlemediated colloidal assembly for prolonged efficacy of bacteriocin against food pathogen / Biotechnol Bioeng 108:1529~1536
Bi L / 2011 / Designing carbohydrate nanoparticles for prolonged efficacy of antimicrobial peptide / J Control Release 150:150~156
Azevedo HS / 2015 / Biomimetic supramolecular designs for the controlled release of growth factors in bone regeneration / Adv Drug Deliv Rev 94:63~76
Baier G / 2013 / Enzyme responsive hyaluronic acid nanocapsules containing polyhexanide and their exposure to bacteria to prevent infection / Biomacromolecules 14:1103~1112
Bi L / 2011 / Carbohydrate nanoparticlemediated colloidal assembly for prolonged efficacy of bacteriocin against food pathogen / Biotechnol Bioeng 108:1529~1536
Bi L / 2011 / Designing carbohydrate nanoparticles for prolonged efficacy of antimicrobial peptide / J Control Release 150:150~156
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