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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 309 - 316 (8page)
- DOI
- 10.15324/kjcls.2021.53.4.309
이용수
초록· 키워드
오류제보하기
Sepsis is a physiological response to a source of infection that triggers mechanisms that compromise organ function, leading to death if not treated early. Biomarkers with high sensitivity, specificity, speed, and accuracy that could differentiate sepsis from non-infectious systemic inflammatory response syndrome (SIRS) could bring about a revolution in sepsis treatment. Given the limitations and time required for microbial verification of pathogens, the accurate diagnosis of infection before employing antibiotic therapy is important and clinically necessary. Procalcitonin (PCT), lactate, C-reactive protein (CRP), cytokines, and proadrenomedullin (ProADM) are the common biomarkers used for diagnosis. The procalcitonin (PCT)-guided antibiotic treatment in patients with acute respiratory infections effectively reduces antibiotic exposure and side effects while improving survival rates. The evidence regarding sepsis screening in hospitalized patients is limited. Clinicians, researchers, and healthcare decision-makers should consider these findings and limitations when implementing screening tools, future research, or policy on sepsis recognition in hospitalized patients. The use of biomarkers in pediatric sepsis is promising, although such use should always be correlated with clinical evaluation. Biomarkers may also improve the prediction of mortality, especially in the early phase of sepsis, when the levels of certain pro-inflammatory cytokines and proteins are elevated.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Angus DC / 2001 / Epidemiology of severe sepsis in the United States : analysis of incidence, outcome, and associated costs of care / Crit Care Med 29:1303~1310
Lawrence KL / 2009 / Antimicrobial stewardship in the intensive care unit : advances and obstacles / Am J Respir Crit Care Med 179:434~438
Kutz A / 2015 / Prognostic value of procalcitonin in respiratory tract infections across clinical settings / Crit Care 19:74
Schuetz P / 2017 / Serial procalcitonin predicts mortality in severe sepsis patients : results from the multicenter procalcitonin monitoring sepsis(MOSES)study / Crit Care Med 45:781~789
Seymour CW / 2016 / Assessment of clinical criteria for sepsis : for the third international consensus definitions for sepsis and septic shock(Sepsis-3) / JAMA 315:762~774
Lawrence KL / 2009 / Antimicrobial stewardship in the intensive care unit : advances and obstacles / Am J Respir Crit Care Med 179:434~438
Kutz A / 2015 / Prognostic value of procalcitonin in respiratory tract infections across clinical settings / Crit Care 19:74
Schuetz P / 2017 / Serial procalcitonin predicts mortality in severe sepsis patients : results from the multicenter procalcitonin monitoring sepsis(MOSES)study / Crit Care Med 45:781~789
Seymour CW / 2016 / Assessment of clinical criteria for sepsis : for the third international consensus definitions for sepsis and septic shock(Sepsis-3) / JAMA 315:762~774
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