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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제5호
- 발행연도
- 2015.1
- 수록면
- 589 - 597 (9page)
이용수
이 논문의 연구 히스토리 (2)
2015
PPARγ 길항제로서의 15-Hydroxyeicosatetraenoic acid의 MUC5AC 발현억제 및 지방분화촉진 기전 분석 : Modulating effects of 15-Hydroxyeicosatetraenoic acid on MUC5AC expression and adipogenesis as a PPARγ agonist
송용석
생명공학과
2015.01
학위논문
15-Hydroxyeicosatetraenoic Acid Inhibits Phorbol-12-Myristate-13- Acetate-Induced MUC5AC Expression in NCI-H292 Respiratory Epithelial Cells
송용석
,
김만섭
,
이동훈
외 2명
Journal of Microbiology and Biotechnology
2015.01
학술저널
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초록· 키워드
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It has been reported that overexpression of MUC5AC induced by excessive inflammation leads to airway obstruction in respiratory diseases such as chronic obstructive pulmonary disease and asthma. 15-Hydroxyeicosatetraenoic acid (15-HETE) has been reported to have anti-inflammatory effects, but the role of 15-HETE in respiratory inflammation has not been determined. Therefore, the aim of this study was to investigate the effects of 15-HETE on MUC5AC expression and related pathways. In this study, phorbol-12-myristate-13-acetate (PMA) was used to stimulate NCI-H292 bronchial epithelial cells in order to examine the effects of 15-HETE. 15-HETE inhibited PMA-induced expression of MUC5AC mRNA and secretion of MUC5AC protein. Moreover, 15-HETE regulated matrix metallopeptidase 9 (MMP-9), mitogen-activated protein kinase kinase (MEK), and extracellular signal-regulated kinase (ERK). In addition, 15-HETE decreased the nuclear translocation of specificity protein-1 (Sp-1) transcription factor and nuclear factor κB (NF-κB). Furthermore, 15-HETE enhanced the transcriptional activity of peroxisome proliferator-activated receptor gamma (PPARγ) as a PPARγ agonist. This activity reduced the phosphorylation of protein kinase B (PΚB/Akt) by increasing the expression of phosphatase and tensin homolog (PTEN). In conclusion, 15-HETE regulated MUC5AC expression via modulating MMP-9, MEK/ERK/Sp-1, and PPARγ/PTEN/ Akt signaling pathways in PMA-treated respiratory epithelial cells.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Aikawa T / 1992 / Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack / Chest 101 : 916 ~ 921
Alpert SE / 1993 / Human tracheal epithelial cells selectively incorporate 15-hydroxyeicosatetraenoic acid into phosphatidylinositol / Am. J. Respir. Cell Mol. Biol 8 : 273 ~
Blanquart C / 2003 / Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation / J. Steroid Biochem. Mol. Biol 85 : 267
Brash AR / 1997 / Discovery of a second 15S-lipoxygenase in humans / Proc. Natl. Acad. Sci. USA 94 : 6148 ~ 6152
Burgel PR / 2008 / Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases / Eur. Respir. J 32 : 1068 ~ 1081
Alpert SE / 1993 / Human tracheal epithelial cells selectively incorporate 15-hydroxyeicosatetraenoic acid into phosphatidylinositol / Am. J. Respir. Cell Mol. Biol 8 : 273 ~
Blanquart C / 2003 / Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation / J. Steroid Biochem. Mol. Biol 85 : 267
Brash AR / 1997 / Discovery of a second 15S-lipoxygenase in humans / Proc. Natl. Acad. Sci. USA 94 : 6148 ~ 6152
Burgel PR / 2008 / Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases / Eur. Respir. J 32 : 1068 ~ 1081
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