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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 843 - 850 (8page)
- DOI
- 10.14348/molcells.2021.0169
이용수
초록· 키워드
오류제보하기
The rapid increase in collateral omics and phenotypic data has enabled data-driven studies for the fast discovery of cancer targets and biomarkers. Thus, it is necessary to develop convenient tools for general oncologists and cancer scientists to carry out customized data mining without computational expertise. For this purpose, we developed innovative software that enables user-driven analyses assisted by knowledge-based smart systems. Publicly available data on mutations, gene expression, patient survival, immune score, drug screening and RNAi screening were integrated from the TCGA, GDSC, CCLE, NCI, and DepMap databases. The optimal selection of samples and other filtering options were guided by the smart function of the software for data mining and visualization on Kaplan-Meier plots, box plots and scatter plots of publication quality. We implemented unique algorithms for both data mining and visualization, thus simplifying and accelerating user-driven discovery activities on large multiomics datasets. The present Q-omics software program (v0.95) is available at http://qomics.sookmyung.ac.kr.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Aran, D. / 2017 / xCell : digitally portraying the tissue cellular heterogeneity landscape / Genome Biol 18:220
Barretina, J. / 2012 / The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity / Nature 483:603~607
Biswas, A. / 2019 / Epistasis and entrenchment of drug resistance in HIV-1 subtype B / Elife 8:e50524
Cancer Genome Atlas Research Network / 2013 / The Cancer Genome Atlas Pan-Cancer analysis project / Nat. Genet 45:1113~1120
Cao, R. / 2020 / An EMTrelated gene signature for the prognosis of human bladder cancer / J. Cell. Mol. Med 24:605~617
Barretina, J. / 2012 / The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity / Nature 483:603~607
Biswas, A. / 2019 / Epistasis and entrenchment of drug resistance in HIV-1 subtype B / Elife 8:e50524
Cancer Genome Atlas Research Network / 2013 / The Cancer Genome Atlas Pan-Cancer analysis project / Nat. Genet 45:1113~1120
Cao, R. / 2020 / An EMTrelated gene signature for the prognosis of human bladder cancer / J. Cell. Mol. Med 24:605~617
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