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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 680 - 687 (8page)
- DOI
- 10.14348/molcells.2021.2249
이용수
초록· 키워드
오류제보하기
Coronavirus disease, COVID-19 (coronavirus disease 2019), caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), has a higher case fatality rate in European countries than in others, especially East Asian ones. One potential explanation for this regional difference is the diversity of the viral infection efficiency. Here, we analyzed the allele frequencies of a nonsynonymous variant rs12329760 (V197M) in the TMPRSS2 gene, a key enzyme essential for viral infection and found a significant association between the COVID-19 case fatality rate and the V197M allele frequencies, using over 200,000 present-day and ancient genomic samples. East Asian countries have higher V197M allele frequencies than other regions, including European countries which correlates to their lower case fatality rates. Structural and energy calculation analysis of the V197M amino acid change showed that it destabilizes the TMPRSS2 protein, possibly negatively affecting its ACE2 and viral spike protein processing.
목차
등록된 정보가 없습니다.
참고문헌 (60)
참고문헌 신청
Adzhubei, I. A. / 2010 / A method and server for predicting damaging missense mutations / Nat. Methods 7:248~249
Altschul, S. F. / 1997 / Gapped BLAST and PSI-BLAST: a new generation of protein database search programs / Nucleic Acids Res 25:3389~3402
Asselta, R. / 2020 / ACE2and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy / Aging (Albany N.Y.) 12:10087~10098
Bhattacharyya, C. / 2020 / Global spread of SARS-CoV-2subtype with spike protein mutation D614G is shaped by human genomic variations that regulate expression of TMPRSS2 and MX1 genes / BioRxiv
Blake, L.E / 2014 / Human genetic variation and yellow fever mortality during 19th century U.S. epidemics / mBio 5:e01253~e01266
Altschul, S. F. / 1997 / Gapped BLAST and PSI-BLAST: a new generation of protein database search programs / Nucleic Acids Res 25:3389~3402
Asselta, R. / 2020 / ACE2and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy / Aging (Albany N.Y.) 12:10087~10098
Bhattacharyya, C. / 2020 / Global spread of SARS-CoV-2subtype with spike protein mutation D614G is shaped by human genomic variations that regulate expression of TMPRSS2 and MX1 genes / BioRxiv
Blake, L.E / 2014 / Human genetic variation and yellow fever mortality during 19th century U.S. epidemics / mBio 5:e01253~e01266
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