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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.8
- 수록면
- 613 - 622 (10page)
- DOI
- 10.14348/molcells.2021.0138
이용수
초록· 키워드
오류제보하기
In vertebrate eyes, the retinal pigment epithelium (RPE) provides structural and functional homeostasis to the retina.
The RPE takes up retinol (ROL) to be dehydrogenated and isomerized to 11-cis-retinaldehyde (11-cis-RAL), which is a functional photopigment in mammalian photoreceptors.
As excessive ROL is toxic, the RPE must also establish mechanisms to protect against ROL toxicity. Here, we found that the levels of retinol dehydrogenases (RDHs) are commonly decreased in phosphatase tensin homolog (Pten)- deficient mouse RPE, which degenerates due to elevated ROL and that can be rescued by feeding a ROL-free diet. We also identified that RDH gene expression is regulated by forkhead box O (FOXO) transcription factors, which are inactivated by hyperactive Akt in the Pten-deficient mouse RPE. Together, our findings suggest that a homeostatic pathway comprising PTEN, FOXO, and RDH can protect the RPE from ROL toxicity.
목차
등록된 정보가 없습니다.
참고문헌 (2)
참고문헌 신청
Jin Woo Kim / 2021 / Tsg101 Is Necessary for the Establishment and Maintenance of Mouse Retinal Pigment Epithelial Cell Polarity / Molecules and Cells 44(3):168~178
Saari, J. C. / 1993 / Retinol esterification in bovine retinal pigment epithelium: reversibility of lecithin:retinol acyltransferase / Biochem. J. 291(Pt 3):697~700
Saari, J. C. / 1993 / Retinol esterification in bovine retinal pigment epithelium: reversibility of lecithin:retinol acyltransferase / Biochem. J. 291(Pt 3):697~700
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