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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 379 - 385 (7page)
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초록· 키워드
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Non-coding RNAs (ncRNAs) comprise various RNA species, including small ncRNAs and long ncRNAs (lncRNAs). ncRNAs regulate various cellular processes, including transcription and translation of target messenger RNAs. Recent studies also indicate that ncRNAs affect organismal aging and coversely aging influences ncRNA levels. In this review, we discuss out current understanding of the roles of ncRNAs in aging and longevity, focusing on recent advances using the roundworm Caenorhabditis elegans. Expression of various ncRNAs, including microRNA (miRNA), tRNA-derived small RNA (tsRNA), ribosomal RNA (rRNA), PIWI-interacting RNA (piRNA), circular RNA (circRNA), and lncRNA, is altered during aging in C. elegans. Genetic modulation of specific ncRNAs affects longevity and aging rates by modulatinf established aging-regulating protein factors. Because many aging-regulating mechanisms in C. elegans are evolutionarily conserved, these studies will provide key information regarding how ncRNAs modulate aging and lifespan in complex organisms, including mammals.
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참고문헌 (64)
참고문헌 신청
Aalto, A. P. / 2018 / Opposing roles of microRNA Argonautes during Caenorhabditis elegans aging / PLoS Genet 14:e1007379
Akay, A. / 2019 / Identification of functional long non-coding RNAs in C. elegans / BMC Biol 17:14
Ozlem Altintas / 2016 / The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster / BMB Reports 49(2):81~92
Batista, P. J. / 2008 / PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans / Mol. Cell 31:67~78
Boehm, M. / 2005 / A developmental timing microRNA and its target regulate life span in C. elegans / Science 310:1954~1957
Akay, A. / 2019 / Identification of functional long non-coding RNAs in C. elegans / BMC Biol 17:14
Ozlem Altintas / 2016 / The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster / BMB Reports 49(2):81~92
Batista, P. J. / 2008 / PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans / Mol. Cell 31:67~78
Boehm, M. / 2005 / A developmental timing microRNA and its target regulate life span in C. elegans / Science 310:1954~1957
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