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Effects of p-coumaric acid on microRNA expression profiles in SNU-16 human gastric cancer cells
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논문 기본 정보

Type
Academic journal
Author
Mi Gyeong Jang (Jeju National University) Hee Chul Ko (Jeju National University) Se‑Jae Kim (Jeju National University)
Journal
한국유전학회 Genes & Genomics Genes & Genomics Vol.42 No.7 KCI Accredited Journals
Published
2020.1
Pages
817 - 825 (9page)

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Effects of p-coumaric acid on microRNA expression profiles in SNU-16 human gastric cancer cells
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Background p-Coumaric acid (p-CA), a phenolic compound abundantly found in edible plants, was found to induce apoptosis in SNU-16 gastric cancer cells. However, the effects of p-CA on the microRNA expression pattern in SNU-16 cells have not been reported. Objectives The primary objective of this study was to investigate microRNA expression profiles in p-CA-treated SNU-16 cells. Methods SNU-16 cells were treated with 1.5 mM p-CA for 48 h. High-throughput RNA sequencing was performed. The accuracy and validity of the RNA sequencing results were tested by real-time PCR. Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed using the differentially expressed microRNAs (DEMs). Results Thirty-two DEMs were identified between p-CA-treated and control cells, 9 of which were upregulated, and 23 downregulated. GO and KEGG pathway analyses of the target genes indicated that these genes were involved in a variety of biological functions and several cancer-related pathways. The miRNA interactive network analysis identified hsa-miR125a-5p, hsa-miR-30a-5p, and hsa-miR-7-5p as the major nodes. Conclusions Our findings indicated that p-CA exerted its anticancer effects in SNU-16 gastric cancer cells by modulating the expression of certain microRNAs, providing a better understanding of the anticancer properties of p-CA in gastric cancer cells.
#MicroRNA · SNU-16 cell · p-Coumaric acid · Next-generation sequencing

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Amini Navaie B / 2015 / Antioxidant and cytotoxic effect of aqueous and hydroalcoholilc extracts of the Ahillea millefolium L. on MCF-7 breast cancer cell line / Int Boil Biomed J 1:119~125 google schola Ding N / 2017 / NEAT1 regulates cell proliferation and apoptosis of ovarian cancer by miR-34a-5p/BCL2 / OncoTargets Ther 10:4905~4915 google schola 엄방울 / 2018 / Trends in Gastric Cancer Incidence According to the Clinicopathological Characteristics in Korea, 1999-2014 / Cancer Research and Treatment 50(4):1343~1350 dbpia Garcia-Martinez O / 2018 / Benefits of olive oil phenolic compounds in disease prevention / Endocr Metab Immune Disord Drug Targets 18:333~340 google schola Gomes CC / 2008 / MicroRNA and oral cancer : future perspectives / Oral Oncol 44:910~914 google schola

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