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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제2호
- 발행연도
- 2021.1
- 수록면
- 171 - 180 (10page)
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Caffeine, a methylxanthine analog of purine bases, is a compound that is largely consumed in beverages and medications for psychoactive and diuretic effects and plays many beneficial roles in neuronal stimulation and enhancement of anti-tumor immune responses by blocking adenosine receptors in higher organisms. In single-cell eukaryotes, however, caffeine somehow impairs cellular fitness by compromising cell wall integrity, inhibiting target of rapamycin (TOR) signaling and growth, and overriding cell cycle arrest caused by DNA damage. Among its multiple inhibitory targets, caffeine specifically interacts with phosphatidylinositol 3-kinase (PI3K)-related kinases causing radiosensitization and cytotoxicity via specialized intermediate molecules. Caffeine potentiates the lethality of cells in conjunction with several other stressors such as oxidants, irradiation, and various toxic compounds through largely unknown mechanisms. In this review, recent findings on caffeine effects and cellular detoxification schemes are highlighted and discussed with an emphasis on the inhibitory interactions between caffeine and its multiple targets in eukaryotic microorganisms such as budding and fission yeasts.
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참고문헌 (105)
참고문헌 신청
Wikoff D / 2017 / Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children / Food Chem. Toxicol 109(Pt 1):585~648
Fredholm BB / 1999 / Actions of caffeine in the brain with special reference to factors that contribute to its widespread use / Pharmacol. Rev 51:83~133
López-Cruz L / 2018 / Caffeine and selective adenosine receptor antagonists as new therapeutic tools for the motivational symptoms of depression / Front. Pharmacol 9:526
Malinauskas BM / 2007 / A survey of energy drink consumption patterns among college students / Nutr. J 6:35
Smith AP / 2013 / Caffeine, extraversion and working memory / J. Psychopharmacol 27:71~76
Fredholm BB / 1999 / Actions of caffeine in the brain with special reference to factors that contribute to its widespread use / Pharmacol. Rev 51:83~133
López-Cruz L / 2018 / Caffeine and selective adenosine receptor antagonists as new therapeutic tools for the motivational symptoms of depression / Front. Pharmacol 9:526
Malinauskas BM / 2007 / A survey of energy drink consumption patterns among college students / Nutr. J 6:35
Smith AP / 2013 / Caffeine, extraversion and working memory / J. Psychopharmacol 27:71~76
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