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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.11
- 수록면
- 855 - 863 (9page)
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Adipose tissue plays a central role in regulating dynamic crosstalk between tissues and organs. A detailed description of molecules that are differentially expressed upon changes in adipose tissue mass is expected to increase our understanding of the molecular mechanisms that underlie obesity and related metabolic co-morbidities. Our previous studies suggest a possible link between endophilins (SH3Grb2 proteins) and changes in body weight. To explore this further, we sought to assess the distribution of endophilin A2 (EA2) in human adipose tissue and experimental animals. Human paired adipose tissue samples (subcutaneous and visceral) were collected from subjects un-dergoing elective abdominal surgery and abdominal liposuction. We observed elevated EA2 gene expression in the subcutaneous compared to that in the visceral human adipose tissue. EA2 gene expression negatively correlated with adiponectin and chemerin in visceral adipose tissue, and positively correlated with TNF-? in subcutaneous adipose tissue. EA2 gene expression was significantly downregulated during differentiation of preadipocytes in vitro. In conclusion, this study provides a description of EA2 distribution and emphasizes a need to study the roles of this protein during the progression of obesity.
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참고문헌 (46)
참고문헌 신청
Alessi, M. C. / 1997 / Production of plasminogen activator inhibitor 1 by human adipose tissue : possible link between visceral fat accumulation and vascular disease / Diabetes 46:860~867
Assim A Alfadda / 2012 / Orosomucoid Serum Concentrations and Fat Depot-Specific mRNA and Protein Expression in Humans / Molecules and Cells 33(1):35~41
Assim A Alfadda / 2012 / Differential Patterns of Serum Concentration and Adipose Tissue Expression of Chemerin in Obesity: Adipose Depot Specificity and Gender Dimorphism / Molecules and Cells 33(6):591~596
Alfadda, A. A. / 2014 / A proteomic analysis of excreted and circulating proteins from obese patients following two different weight-loss strategies / Exp. Biol. Med. (Maywood) 239:568~580
Baldassarre, T. / 2015 / Endophilin A2 promotes TNBC cell invasion and tumor metastasis / Mol. Cancer Res 13:1044~1055
Assim A Alfadda / 2012 / Orosomucoid Serum Concentrations and Fat Depot-Specific mRNA and Protein Expression in Humans / Molecules and Cells 33(1):35~41
Assim A Alfadda / 2012 / Differential Patterns of Serum Concentration and Adipose Tissue Expression of Chemerin in Obesity: Adipose Depot Specificity and Gender Dimorphism / Molecules and Cells 33(6):591~596
Alfadda, A. A. / 2014 / A proteomic analysis of excreted and circulating proteins from obese patients following two different weight-loss strategies / Exp. Biol. Med. (Maywood) 239:568~580
Baldassarre, T. / 2015 / Endophilin A2 promotes TNBC cell invasion and tumor metastasis / Mol. Cancer Res 13:1044~1055
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