지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 35 - 41 (7page)
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Obesity is associated with chronic low-grade inflamma-tion, which contributes to systemic metabolic irregularities and obesity-linked metabolic disorders. Orosomucoid (ORM), an acute phase reactant protein, was shown to be produced in response to metabolic and inflammatory signals in the adipose tissue of obese mice, which protects them from severe inflammation and subsequent metabolic dysfunction. In this study, we examined whether there are site-specific differences between visceral and subcutaneous adipose tissue (VAT and SAT, respectively) ORM gene and protein expression from individuals with a wide range of obesity and the relationship between expressed and circulating ORM levels and measures of adiposity, insulin resistance, and pro- and anti-inflammatory markers and adipokines. The level of circulating ORM correlated positively with BMI, body fat mass, and serum leptin. It also correlated with fasting insulin, HOMA-IR values and C-reactive protein in men. There were no site-specific differences in ORM mRNA and protein expression between VAT and SAT, nor did we find a relationship between circulating ORM levels and its mRNA expression in either fat depot. We found that ORM mRNA expression correlated with mRNA expression of TNF-?, IL-6, and adiponectin in VAT, and with TNF-? and adiponectin in SAT. These observations are the first description linking adipose tissue ORM and pro- and anti-inflammatory molecules in humans. The close links of ORM and measures of adiposity, insulin resistance, and adipose tissue inflammation in humans reinforce previous experimental data and warrant further studies to explore a possible role of ORM in the patho-genesis of obesity-associated metabolic derangements.
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참고문헌 (28)
참고문헌 신청
Ahima, R. S. / 2000 / Adipose tissue as an endocrine organ / Trends Endocrinol. Metab 11:327~332
Alberti, K. G. / 2006 / Metabolic syndrome-a new world-wide definition. A consensus statement from the international diabetes federation / Diabet. Med 23:469~480
Alessi, M. C. / 1997 / Production of plasminogen activator inhibitor 1 by human adipose tissue : possible link between visceral fat accumulation and vascular disease / Diabetes 46:860~867
Benedek, I. H. / 1983 / Serum alpha 1-acid glycoprotein and the binding of drugs in obesity / Br. J. Clin. Pharmacol 16:751~754
Benedek, I. H. / 1984 / Serum protein binding and the role of increased alpha 1-acid glycoprotein in moderately obese male subjects / Br. J. Clin. Pharmacol 18:941~946
Alberti, K. G. / 2006 / Metabolic syndrome-a new world-wide definition. A consensus statement from the international diabetes federation / Diabet. Med 23:469~480
Alessi, M. C. / 1997 / Production of plasminogen activator inhibitor 1 by human adipose tissue : possible link between visceral fat accumulation and vascular disease / Diabetes 46:860~867
Benedek, I. H. / 1983 / Serum alpha 1-acid glycoprotein and the binding of drugs in obesity / Br. J. Clin. Pharmacol 16:751~754
Benedek, I. H. / 1984 / Serum protein binding and the role of increased alpha 1-acid glycoprotein in moderately obese male subjects / Br. J. Clin. Pharmacol 18:941~946
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